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SDIMMMER: A Proposed Clinical Approach to Optimize Cellular Physiology in Regenerative Medicine

2024; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 10 Linguagem: Inglês

10.3390/life14101287

2075-1729

João Vitor Lana, José Fábio Lana, Gregory Melo, Gabriel Ohana Marques Azzini, Gabriel Silva Santos, Tomas Mosaner, Daniel de Moraes Ferreira Jorge, Lucas Furtado da Fonseca, André Kruel, Fábio Ramos Costa, Madhan Jeyaraman, Alex Pontes de Macedo, Napoliane Santos, Luyddy Pires, Cláudia Herrera Tambeli,

3D Printing in Biomedical Research

SDIMMMER is an acronym intended for use in both clinical practice and medical research. It facilitates a comprehensive evaluation of a patient’s metabolic profile and serves as a mnemonic for the following key assessment areas: Sleep, Diet, Microbiome, Metabolism, Medications, Exams, and Rehabilitation. In the clinical setting, SDIMMMER’s primary objective is to monitor and manage the patient’s metabolic status, particularly targeting low-grade chronic systemic inflammation, a hallmark of metabolic syndrome (MS). This inflammatory condition is characterized by elevated levels of circulating inflammatory cytokines and increased macrophage infiltration in peripheral tissues. SDIMMMER aims to enhance the effectiveness of ortho biological treatments by elevating growth factor levels, thereby enhancing patient outcomes. Additionally, SDIMMMER emphasizes guiding patients toward positive lifestyle changes to improve overall quality of life and foster a healthier metabolism. SDIMMMER introduces a patient metabolic profile quantification tool comprising 7 domains, totaling 35 items. Additionally, an instructional guide is provided to facilitate the application process. Its versatility spans various clinical and research domains, showcasing its potential to positively influence multiple fields.