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Impaired unsaturated fatty acid elongation alters mitochondrial function and accelerates metabolic dysfunction-associated steatohepatitis progression

2024; Elsevier BV; Volume: 162; Linguagem: Inglês

10.1016/j.metabol.2024.156051

1532-8600

Adrien Vouilloz, Thibaut Bourgeois, Marc Diedisheim, Thomas Pilot, Antoine Jalil, Naïg Le Guern, Victoria Bergas, Noéline Rohmer, Florence Castelli, Damien Leleu, Alexis Varin, Jean-Paul Paı̈s de Barros, Pascal Degrace, Mickaël Rialland, Camille Blériot, Nicolas Venteclef, Charles Thomas, David Masson,

Diet, Metabolism, and Disease

Although qualitative and quantitative alterations in liver Polyunsaturated Fatty Acids (PUFAs) are observed in MASH in humans, a causal relationship of PUFAs biosynthetic pathways is yet to be clarified. ELOVL5, an essential enzyme in PUFA elongation regulates hepatic triglyceride metabolism. Nonetheless, the long-term consequences of elongase disruption, particularly in murine models of MASH, have not been evaluated.