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Prevalence, Phenotypes, and Comorbidities of Polycystic Ovary Syndrome Among Indian Women

2024; American Medical Association; Volume: 7; Issue: 10 Linguagem: Inglês

10.1001/jamanetworkopen.2024.40583

2574-3805

Mohd Ashraf Ganie, Subhankar Chowdhury, Neena Malhotra, Rakesh Sahay, Prasanta Kumar Bhattacharya, Sarita Agrawal, Puthiyaveettil Khadar Jabbar, Vanita Suri, Roya Rozati, Vishnubhatla Sreenivas, Mohammad Salem Baba, Imtiyaz Ahmad Wani, Haroon Rashid, Abhilash Nair, Amlin Shukla, Taruna Arora, Bharati Kulkarni, Parvaiz A Koul, Zafar A. Shah, Shariq Rashid Masoodi, Tariq Parvez, Ghulam Nabi Yatoo, Nicole Chow, Tariq Gojwari, Muzaffar Wani, Seema Qayoom, Wahid Ali Khan, Rama Walia, Deepenkar De, Aashima Arora, Tulika Singh, Neena Khanna, Nitish Naik, Shyam Prakash, Nandita Gupta, Rajesh Sagar, Jai Bhagwan Sharma, Devasenathipathy Kandasamy, Narender Kuber Bodhey, Eli Mohapatra, Sabah Siddiqui, Gourisankar Kamilya, Archana Singh, Pradip Mukhopadhyay, Nehar Ranjan Sarkar, Alice Abraham Ruram, Jessy Abraham, Donboklang Lynser, Manika Agrawal, Lin Rao, Sudha Bindu, Malathi Ponnuru, Nadeem Ahmad, Sujatha Rani, Aleem Ahmad Khan, Sultan Rizwan Ahmad, Prabhakar Rao, Nirmala Chongtham, Anuja Elizabeth George, Jayasree Leelamma, Gaurav Thakur, Saba Noor, Khursheed Paddar, Gaivee Vinam Meshram, Sewa Ram Choudhary, Aafia Rashid, Wasia Showkat, Rohina Bashir, Rabiya Rashid, Jaida Manzoor, Nisar Ahmad, Pieu Adhikary, Subhasish Pramanik, Rahul Harish, Mudasir Makhdoomi, Mudasir Fayaz, Nafeez Rehman, Neha Ravi, Ajay Kumar, Siffali Chandrakar, Nithlesh Kumar, Sudipta Banerjee, Humaira Minhaj, B. Bhaskar, Shaik Iqbal, Babu Ram, Arya Suresh, RS Sharma, Shalini Singh, Malabika Roy, Reeta Rasilly, Nomita Chandiok, M. Rajab, A. R. Reshi, Deeba Farhat, Abid Rashid, Nusrat Jahan, Sewa Ram Choudhary, Naila Mohiudin, Ranjith Sreedharan, Khalid ul Islam Rather,

Reproductive Biology and Fertility

Importance The prevalence of polycystic ovary syndrome (PCOS) varies across the globe. Indian studies on PCOS are limited by poor design, small sizes, regional representations, and varying methods. Objectives To estimate the nationwide prevalence of PCOS in India, examine the phenotypic spectrum, and assess the magnitude of comorbidities associated with PCOS. Design, Setting, and Participants This cross-sectional study recruited 9824 women aged 18 to 40 years from November 1, 2018, to July 31, 2022, across 5 zones of the country. A prevalidated questionnaire dichotomized women into screen-positive and screen-negative groups. Relevant clinical, hormonal, and sonographic assessments categorized women as either women with criteria-based PCOS (ie, National Institutes of Health [NIH] 1990 criteria, Rotterdam 2003 criteria, or Androgen Excess and Polycystic Ovary Syndrome Society [AE-PCOS] criteria), women with partial phenotypes (hyperandrogenism, oligomenorrhea, or polycystic morphology labeled as pre-PCOS), or healthy women, in addition to quantitating various comorbidities. Main Outcomes and Measures The prevalence and phenotypes of PCOS among women of reproductive age and the burden of comorbidities associated with PCOS. Results A total of 8993 women (mean [SD] age, 29.5 [6.2] years) were enrolled in this study; 196 women were already diagnosed with PCOS, 2251 were categorized as screen positive, and 6546 were categorized as screen negative. The mean (SD) age of screen-positive women (28.1 [6.4] years) was lower than that of screen-negative women (29.7 [6.1] years) ( P < .001), and the mean (SD) age at menarche was higher in the former group (13.2 [1.3] vs 13.1 [1.2] years; P < .001). The national prevalence of PCOS was 7.2% (95% CI, 4.8%-10.8%) by NIH 1990 criteria, 19.6% (95% CI, 12.7%-29.2%) by Rotterdam 2003 criteria, and 13.6% (95% CI, 8.4%-21.6%) by AE-PCOS criteria. Overall, PCOS phenotypes C (501 [40.8%]) and D (301 [24.6%]) were the most common, and 492 women (pre-PCOS subgroup) had oligomenorrhea (n = 75), hyperandrogenism (n = 257), or polycystic ovarian morphology (n = 160) only. Among women with PCOS (n = 1224), obesity was present in 529 (43.2%), dyslipidemia in 1126 (91.9%), nonalcoholic fatty liver disease in 403 (32.9%), metabolic syndrome in 305 (24.9%), impaired glucose tolerance in 111 (9.1%), diabetes in 41 (3.3%), and hypertension in 101 (8.3%). The pre-PCOS subgroup (n = 492) displayed similar metabolic aberrations (dyslipidemia: 390 [79.3%]; metabolic syndrome: 78 [15.9%]; nonalcoholic fatty liver disease: 163 [33.1%]; impaired glucose tolerance: 62 [12.6%]; diabetes: 7 [1.4%]; and hypertension: 26 [5.3%]). Conclusions and Relevance In this cross-sectional study of reproductive-age women recruited across India, the prevalence of PCOS was high, with phenotype C being predominant. Most of these women had metabolic abnormalities. These findings are crucial for developing preventive and therapeutic strategies, potentially integrating PCOS management into national health programs.