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Extramedullary disease in Waldenström macroglobulinemia: A population‐based observational study

2024; Wiley; Volume: 5; Issue: 6 Linguagem: Inglês

10.1002/jha2.1037

2688-6146

Simon Østergaard, Lars Munksgaard, Torsten Holm Nielsen, Troels Hammer, Lars Møller Pedersen, Mette Ølgod Pedersen, Lise Mette Rahbek Gjerdrum,

Renal Diseases and Glomerulopathies

Abstract Introduction: Extramedullary disease (EMD) is a rare manifestation of Waldenström macroglobulinemia (WM), and its clinical and prognostic implications are poorly understood. Methods: In this single‐center study, we investigated the clinical significance of EMD in a cohort of 469 WM patients. Results: EMD was identified in 30 (6.4%) patients, with the central nervous system, kidneys, and lungs being the most frequently affected sites. The cumulative incidence of EMD was 12.6% at 15 years. Median overall survival rates at 5 and 10 years for patients with EMD were 63% and 37%, respectively. Conclusion: Our findings indicate a persistent risk of EMD throughout the disease course, with no significant impact on long‐term survival.