Efficacy and Low Toxicity of Normo-Fractionated Re-Irradiation with Combined Chemotherapy for Recurrent Glioblastoma—An Analysis of Treatment Response and Failure
2024; Multidisciplinary Digital Publishing Institute; Volume: 16; Issue: 21 Linguagem: Inglês
10.3390/cancers16213652
ISSN2072-6694
AutoresNiklas Benedikt Pepper, Nicholas Grischa Prange, Fabian M. Troschel, Kai Kroeger, Michael Oertel, Tanja Kuhlmann, Michael Müther, Oliver Grauer, Walter Stummer, Hans Theodor Eich,
Tópico(s)Ocular Oncology and Treatments
ResumoGlioblastoma is the most common malignant brain tumor in adults. Even after maximal safe resection and adjuvant chemoradiotherapy, patients normally relapse after a few years or even months. Standard treatment for recurrent glioblastoma is not yet defined, with re-resection, re-irradiation, and systemic therapy playing key roles. Usually, re-irradiation is combined with concurrent chemotherapy, harnessing the radiosensitizing effects of alkylating agents.
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