The causal role of gastroesophageal reflux disease in endometriosis: a bidirectional Mendelian randomization study
2024; Frontiers Media; Volume: 11; Linguagem: Inglês
10.3389/fmed.2024.1440157
ISSN2296-858X
AutoresZhonghua Shi, Zhi Li, Kana Wang, Fan Yang,
Tópico(s)Gynecological conditions and treatments
ResumoObservational studies have reported an association between gastroesophageal reflux disease (GERD) and endometriosis. We conducted a two-sample and bidirectional Mendelian randomization analysis to determine whether those associations are causal. Two-sample and bidirectional MR analyses were performed using summary statistics from the European Individual Genome-Wide Association Study (GWAS). The inverse variance weighting (IVW) method is used as the main analysis method to evaluate causality. Sensitivity analyses were performed to assess heterogeneity, horizontal versatility, and stability. The results showed no significant causal association between GERD in women with endometriosis in the UK Bank database [ratio (OR) ≈ 0, 95% adjusted interval (CI) 1.0007∼1.0044,
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