Artigo Acesso aberto Revisado por pares

The causal role of gastroesophageal reflux disease in endometriosis: a bidirectional Mendelian randomization study

2024; Frontiers Media; Volume: 11; Linguagem: Inglês

10.3389/fmed.2024.1440157

ISSN

2296-858X

Autores

Zhonghua Shi, Zhi Li, Kana Wang, Fan Yang,

Tópico(s)

Gynecological conditions and treatments

Resumo

Observational studies have reported an association between gastroesophageal reflux disease (GERD) and endometriosis. We conducted a two-sample and bidirectional Mendelian randomization analysis to determine whether those associations are causal. Two-sample and bidirectional MR analyses were performed using summary statistics from the European Individual Genome-Wide Association Study (GWAS). The inverse variance weighting (IVW) method is used as the main analysis method to evaluate causality. Sensitivity analyses were performed to assess heterogeneity, horizontal versatility, and stability. The results showed no significant causal association between GERD in women with endometriosis in the UK Bank database [ratio (OR) ≈ 0, 95% adjusted interval (CI) 1.0007∼1.0044,

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