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A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest

2024; Massachusetts Medical Society; Linguagem: Inglês

10.1056/nejmoa2407780

1533-4406

Keith Couper, Chen Ji, Charles D. Deakin, Rachael Fothergill, Jerry P. Nolan, John Long, James Mason, Felix Michelet, Chloe Norman, Henry Nwankwo, Tom Quinn, Anne‐Marie Slowther, Michael A. Smyth, Kath Starr, Alison Walker, Sara Wood, Steve Bell, Gemma Bradley, Martina Brown, Shona Brown, Emma Burrow, Karl Charlton, Andrew Claxton Dip, Victoria L Dra'gon, C. V. Evans, J Falloon, Theresa Foster, Justin Kearney, Nigel Lang, Matthew Limmer, Adam Smith, Josh Miller, Carla Mills, Ria Osborne, Nigel Rees, Robert Spaight, Garry Squires, Belinda Tibbetts, M. S. Waddington, Gregory Adam Whitley, Jason A. Wiles, Julia Williams, S. Wiltshire, Adam Wright, Ranjit Lall, Gavin D. Perkins,

Emergency and Acute Care Studies

In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinephrine is highly time-dependent. An intraosseous route of drug administration may enable more rapid drug administration than an intravenous route; however, its effect on clinical outcomes is uncertain.