Editorial: “2024 Emerging Investigators”
2024; American Chemical Society; Volume: 35; Issue: 11 Linguagem: Inglês
10.1021/jasms.4c00375
ISSN1879-1123
Autores Tópico(s)Health and Medical Research Impacts
ResumoInfoMetricsFiguresRef. Journal of the American Society for Mass SpectrometryVol 35/Issue 11Article This publication is free to access through this site. Learn More CiteCitationCitation and abstractCitation and referencesMore citation options ShareShare onFacebookX (Twitter)WeChatLinkedInRedditEmailJump toExpandCollapse EditorialNovember 6, 2024Editorial: "2024 Emerging Investigators"Click to copy article linkArticle link copied!Erin S. Baker*Erin S. Baker*[email protected]More by Erin S. BakerHelen J. Cooper*Helen J. Cooper*[email protected]More by Helen J. CooperOpen PDFJournal of the American Society for Mass SpectrometryCite this: J. Am. Soc. Mass Spectrom. 2024, 35, 11, 2547–2553Click to copy citationCitation copied!https://pubs.acs.org/doi/10.1021/jasms.4c00375https://doi.org/10.1021/jasms.4c00375Published November 6, 2024 Publication History Received 12 September 2024Published online 6 November 2024Published in issue 6 November 2024editorialCopyright © 2024 American Society for Mass Spectrometry. Published by American Chemical Society. All rights reserved. This publication is available under these Terms of Use. Request reuse permissionsThis publication is licensed for personal use by The American Chemical Society. ACS PublicationsCopyright © 2024 American Society for Mass Spectrometry. Published by American Chemical Society. All rights reserved.Subjectswhat are subjectsArticle subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article.Analytical chemistryCancerIonsMass spectrometryProteomicsSPECIAL ISSUEThis article is part of the 2024 Emerging Investigators special issue.In this issue of the Journal of the American Society for Mass Spectrometry, we are delighted to highlight the work of 19 early career researchers. Their articles comprise the 2024 ASMS "Emerging Investigators" Special Issue and represent a truly global issue with contributors from across the USA, Europe and Australia. The investigators come from a variety of disciplines, working in academia, industry and national laboratories. Furthermore, their articles have a wide range of topics, covering both experimental and computational mass spectrometry science, software and hardware developments, and applications in structural biology, inorganic chemistry, spatial biology, microbiology and proteomics, both bottom-up and top-down.The goal of the annual Emerging Investigators Special Issue is to showcase some of the exciting independent work being performed by early career researchers. These individuals have demonstrated their potential to make important contributions to their respective areas of research and become future leaders within the field. Authors were invited to contribute articles for peer review based on recommendations from the Editor-in-Chief, Associate Editors, members of the Editorial Board of JASMS, members of the ASMS Board of Directors, and other prominent mass spectrometrists. Brief biographical sketches for the emerging investigators are also included in this issue to highlight their diverse backgrounds and illustrate what has influenced their current and future research interests. We would like to thank each of the investigators for their contributions and look forward to following their career progression in the decades to come.Dr. Bilbao is a Computational Scientist at Pacific Northwest National Laboratory (PNNL), leading the development of advanced algorithms and software tools for mass spectrometry and Artificial Intelligence/Machine Learning (AI/ML) integration in scientific instrumentation. She earned her Bachelor's degree in Computer Engineering (cum laude) from Universidad de Oriente, Venezuela, and her MSc in Automatic Data Processing, focused on ML and statistical methods, from Telecom SudParis and Université de Versailles Saint-Quentin-en-Yvelines, France. She began her career in mass spectrometry during her graduate studies under the guidance of Prof. Gérard Hopfgartner and Prof. Frédérique Lisacek, at the University of Geneva and the SIB Swiss Institute of Bioinformatics, where she developed innovative software tools for data-independent acquisition proteomics and metabolomics. After obtaining her PhD in Interdisciplinary Sciences/Computational Biology in 2016 in Switzerland, she joined PNNL in the United States as a postdoctoral fellow, where she has been developing computational mass spectrometry tools for ion mobility spectrometry and contributing to high-impact projects. Since 2019, she has continued this work as staff.Dr. Bilbao's expertise encompasses various omics types, analytical separations, MS instrumentation, and programming languages. Her current work leverages modern AI to create advanced scientific software for interdisciplinary research spanning biology, biotechnology, and environmental sciences at PNNL and the Environmental Molecular Sciences Laboratory user program.Committed to advancing computational MS and AI/ML research, Dr. Bilbao develops user-friendly scientific software and actively mentors interns, fostering the next generation of scientists while promoting diversity through inclusive research practices. She is an active member of the American Society for Mass Spectrometry, contributing to organize conference workshops and sessions, and serving as journal peer reviewer and guest editor. She was awarded the JASMS Outstanding Reviewer Award in 2023.Nicholas B. Borotto is an Assistant Professor at University of Nevada, Reno. He received his B.S. in Biochemistry from Northeastern University. In this time, he was first introduced to mass spectrometry while performing research in Prof. John Engen's laboratory. He then moved to the University of Massachusetts Amherst to get his Ph.D. in Chemistry with Prof. Richard Vachet. To conclude his training, he was a postdoctoral fellow at the University of Michigan where he was coadvised by Profs. Kristina Håkansson and Brent Martin. He began his independent career in 2019 and his research program utilizes chemical derivatization, photon irradiation, ion mobility spectrometry, and radical chemistry to sequence and assess the higher-order structure of proteins.Chris Chouinard is an Assistant Professor in the Department of Chemistry at Clemson University. He received B.S. degrees in Chemistry and Biology from UNC-Chapel Hill and completed his Ph.D. in Chemistry at University of Florida with Prof. Rick Yost. During his graduate studies, he developed ion mobility-mass spectrometry (IM-MS) methods for analysis of steroidal compounds. He then completed his postdoctoral work with Dr. Dick Smith at Pacific Northwest National Laboratory (PNNL), where he helped to develop Structures for Lossless Ion Manipulations (SLIM) ion mobility for a variety of bioanalytical applications. Following four years at Florida Tech, Chris joined the faculty at Clemson in Fall 2022 where his group now specializes in IM-MS methods and technology (including continued development of SLIM) for illicit compounds such as performance-enhancing drugs and novel psychoactive substances.Christopher M. Crittenden is a Principal Scientist at Genentech in South San Francisco, California. He received his Bachelor of Science degree in Chemistry from the University of West Georgia (Carrollton, GA) under the guidance of Dr. Farooq A. Khan. He then moved to the University of Texas at Austin (Austin, TX) and receiving his Ph.D. in Analytical Chemistry in Dr. Jennifer S. Brodbelt's research lab developing novel applications for photodissociation of biological molecules. At the end 2018, Christopher started in the Structure Elucidation Group at Genentech in the Synthetic Molecule Analytical Chemistry department where he implements advanced mass spectrometry techniques for the characterization of synthetic pharmaceutical compounds including alternative fragmentation and separation strategies. His alma mater, University of West Georgia, recognized him as a recipient of the Thriving Under Thirty award in the Fall of 2020. In his spare time, he can be found on the softball diamond coaching his daughter's little league team and cheering on both of his kids on the soccer pitch with his wife Shastina.Dr. Brad Clarke is currently a Senior Lecturer in Environmental Science & Analytical Chemistry at the University of Melbourne (Australia) and chief investigator at the Australian Laboratory for Emerging Contaminants (ALEC). Brad's research focuses on assessing the risk to public health and the environment from pollution, focusing on synthetic per and polyfluoroalkyl substances (PFAS), microplastics and flame retardants as well as advanced mass spectrometry techniques. Brad is passionate about industry-engaged, conducting applied and fundamental research to address real-world problems. Previously, Brad was the Environmental Science degree senior program manager at RMIT University and has held postdoctoral positions at Imperial College London and the University of Arizona.Daniel Deredge is a tenure-track Assistant Professor at the University of Maryland School of Pharmacy. He completed his Ph.D. in Biochemistry from Louisiana State University, where he studied the DNA binding properties of bacterial DNA polymerases. Following his doctoral work, Daniel completed postdoctoral training in structural mass spectrometry at Case Western Reserve University, where he was introduced to Hydrogen–Deuterium exchange mass spectrometry (HDX-MS) in the context of viral polymerases. Subsequently, as a postdoctoral scholar and then a research assistant professor at the University of Maryland, Daniel expanded the application of HDX-MS and other structural mass spectrometry methods to a variety of systems, including viral RNA polymerases, bacterial heme uptake proteins, and neurotransmitter symporters, while developing a framework to integrate these approaches with computational methods. In 2021, he established the Deredge Lab within the Department of Pharmaceutical Sciences. His research is centered on developing and applying integrative approaches that combine mass spectrometry-based biophysical approaches, with an emphasis on HDX-MS, with computational modeling and simulations to investigate protein structure and dynamics and protein/ligand interactions. In addition, the lab focuses on the structural and conformational analysis of the RNA-dependent RNA polymerase from the Dengue virus (Non-Structural 5 protein, NS5), with the goal of developing novel therapeutics against Dengue.Shane R. Ellis is an Associate Professor at the University of Wollongong. He obtained his PhD from the University of Wollongong (UOW) in 2013 before completing a postdoctoral position with Prof. Ron Heeren at FOM-AMOLF in Amsterdam where he worked on the development of Timepix active pixel detectors for various ion imaging applications. From 2014 to 2019 he was an Assistant Professor at the Maastricht MultiModal Molecular Imaging Institute (M4I) where he led the Imaging Instrumentation and Application Development Group within the Division for Imaging Mass Spectrometry. In 2018 he was awarded a prestigious VIDI grant from The Netherlands Organization and returned to Australia in 2020 as an Australian research Council Future Fellow. He has won several awards for his research including in 2022 the Jochen Franzen Award from the International Mass Spectrometry Foundation and in 2018 the Outstanding Research Award from The Netherlands Mass Spectrometry Society. He was also named in the 2022 Analytical Scientist 40 under 40 Power list. His research focuses on both the continued development of MSI technologies and their application to studying region-specific metabolism in tissues and cells, with a particular focus on lipidomics.Ahmed Hamid is an Assistant Professor in the Department of Chemistry and Biochemistry at Auburn University. He received his PhD degree in Physical Chemistry from Virginia Commonwealth University in 2012 under the supervision of Prof. Samy El-Shall working on gas-phase ion chemistry. He did postdoctoral research with Prof. Graham Cooks at Purdue University from 2012 to 2014 and at Pacific Northwest National Laboratory with Dr. Richard D. Smith from 2014 to 2017. Then, he became a Senior Scientist at MOBILion Systems, Inc. from 2017 to 2019 before joining Auburn University in August 2019. His research is focused on the development of novel mass spectrometry instruments, in particular those utilizing ion mobility separations for several applications in clinical and environmental research areas. He was awarded the R&D 100 award in 2017.Komal Kedia is an Associate Principal Scientist at Merck & Co. within Pharmacokinetics, Dynamics, Metabolism & Bioanalytics (PDMB) group. She received her Bachelor's in Pharmaceutical Sciences from Delhi University in New Delhi, India, and her Ph.D. in Analytical Chemistry from Brigham Young University under the mentorship of Dr. Steven Graves. In Dr. Graves's lab, she utilized high-resolution mass spectrometry to identify placental proteins and lipid markers of a pregnancy-related condition called Preeclampsia to gain a deeper understanding of the pathophysiology of this disorder. Following graduation, she completed her postdoctoral training at Pacific Northwest National Lab (PNNL) in Dr. Richard Smith's group, where she participated in multiple projects, including biomarker discovery for several diseases and method development for xenobiotics profiling using advanced separation and mass spectrometry approaches. In her current role at Merck, she supports PK/PD studies for small molecules across different internal programs in the preclinical space. Additionally, her research involves the utilization of high-resolution ion mobility-MS techniques to tackle the unique challenges posed by complex molecules. Her research encompasses diverse applications, ranging from investigating lipid biomarkers in support of neuroscience pipelines to metabolite identification of cyclic peptide therapeutics.Dr. Sonja Klee is Product Manager at TOFWERK, a leading mass spectrometer manufacturer based in Switzerland. Her journey in mass spectrometry began during her undergraduate studies in Chemistry at the University of Wuppertal, Germany, where she delved into ionization and mass spectrometry fundamentals under the guidance of Professor Thorsten Benter. Both fundamental research and practical applications continued through her academic studies and culminated in her doctoral thesis defense in Physical Chemistry in 2014 focusing on chemical ionization mechanisms used in mass spectrometry. For this achievement, she was honored with the Wolfgang-Paul-Study Award from the German Society for Mass Spectrometry (DGMS). Following her PhD, Dr. Klee was awarded a Postdoctoral Marie Curie Fellowship from TOFWERK to contribute to the CLOUD TRAIN Network at CERN, Switzerland. During this tenure, she took part in conducting complex experiments as part of the EU research program "CLOUD,″ utilizing various TOFWERK mass spectrometers. After her two-year postdoctoral position, she continued within the company, leveraging her expertise in ionization and mass spectrometry development in several key roles, including Leading Coordinator for Ion Source Technology (2016–2020) and Project Manager (2016-present). Dr. Klee's extensive research background and industrial experience have significantly contributed to the development and industrialization of the ecTOF product line, a breakthrough solution for GC-MS based compound identification. The culmination of her efforts was marked by the launch of the ecTOF product line in collaboration with Bruker at the American Society of Mass Spectrometry (ASMS) conference in 2024. Recognized for her expertise and leadership in the field, Dr. Klee was elected as an official board member of the Swiss Group for Mass Spectrometry (SGMS) in 2023. In this capacity, she oversees the "Education" portfolio among other responsibilities, reflecting her commitment to advancing knowledge and innovation in mass spectrometry.Franklin E. Leach III is an Assistant Professor in the Department of Chemistry at the University of Georgia. He completed a B.S. in Chemistry at Mississippi State University followed by a period of employment in the environmental sector. He later earned a Ph.D. in Analytical Chemistry under the direction of Professor I. Jonathan Amster at the University of Georgia. Prior to joining the faculty at UGA, he was a postdoctoral research associate and staff scientist in the Department of Energy's Pacific Northwest National Laboratory Environmental Molecular Sciences Laboratory. The research program in the leach lab seeks to be a torch bearer for FTMS fundamentals and instrumentation in an age of black box platforms and push button science. Current interests are focused on the development of FTMS based approaches that both enhance and democratize the ability of the scientific community to make high performance mass measurements related to complex mixture analysis and MS imaging.Dr. Jennifer L Lippens earned her B.S. in Forensic Science and Chemistry from Russell Sage College (USA). She started her career in mass spectrometry under the mentorship of Dr. Daniele Fabris at the State University of New York at Albany where she employed ion mobility mass spectrometry to study the gas phase structure of large nucleic acids. Following her Ph.D., she pursued postdoctoral research at Amgen under the comentorship of Dr. Iain Campuzano (Amgen) and Dr. Joseph Loo (UCLA) using mass spectrometry to study membrane proteins and their complexes. At Amgen she continued in mass spectrometry as a staff scientist, expanding her application of mass spectrometry for oligonucleotide analysis as well as to other modalities before moving to J&J in Belgium. At J&J, she is continuing her work in mass spectrometry and its application across multiple modalities. She is the author and coauthor of several peer-reviewed publications in nucleic acid mass spectrometry.Jennifer Meyer studied chemistry at the Technische Universität Kaiserslautern, Germany. After finishing with a Diploma in 2008, she joined the group of Gereon Niedner-Schatteburg for her PhD work on the magnetism of isolated clusters in gas phase by XMCD spectroscopy. She finished her PhD in 2014 and moved to Innsbruck to join the group of Roland Wester as a postdoctoral researcher, where she learned about crossed beam velocity map imaging to study the dynamics of ion molecule reactions, especially the competition between elimination and substitution reactions. She started her own research project supported by the FWF on the dynamics bond activation in small molecules by transition metal ions in 2018. In 2020 she returned to Kaiserslautern to join the chemistry faculty as a Junior-Professor. Here she established her own research group, where she continuous to study the dynamics of bond breaking and forming reactions mediated by transition metal ions. A special interest is placed in the influences electronic states exert on the dynamics of a reactionIn 2017, Dr. Gabe Nagy completed his Ph.D. in analytical chemistry at Indiana University under the mentorship of Dr. Nicola L. B. Pohl where he worked to develop mass spectrometry-based methods for improved monosaccharide identification. Following graduate school, Dr. Nagy transitioned to working in Dr. Richard D. Smith's lab at Pacific Northwest National Laboratory. His postdoctoral work involved the application of high-resolution IMS-MS in structures for lossless ion manipulations (SLIM) for the ultrafast separation of various biomolecules, with a particular emphasis on previously inseparable species, such as glycans, phosphopeptides, antibody drug conjugates, beta amyloid peptide fragments, and other metabolites. In 2020, Dr. Nagy began his independent career as an Assistant Professor in the Department of Chemistry at the University of Utah. His group focuses on the use of cyclic ion mobility spectrometry-mass spectrometry-based separations to address the many challenges associated with the characterization of human milk oligosaccharides as well as continuing to explore the fundamental nature behind mass distribution-based isotopic shifts.Elizabeth Neumann is an assistant professor in the chemistry department at UC Davis. Her research focuses on understanding the molecular and cellular architecture behind complex human disorders, such as renal cell carcinoma, spina bifida, and Alzheimer's Disease. This highly interdisciplinary research involves developing analytical tools and multimodal imaging methods for understanding complex biological phenomena. She has a passion for mentorship, outreach, and board games. Before joining UC Davis, she was a National Institutes of Health postdoctoral fellow at Vanderbilt University in Nashville, Tennessee and an NSF graduate fellow at the University of Illinois at Urbana–Champaign, Urbana, Illinois.Amanda Patrick is an Associate Professor in the Department of Chemistry at Mississippi State University. She earned her BS in Chemistry from North Carolina State University and her PhD in Chemistry from the University of Florida, working with Prof. Nicolas Polfer. She then went on to complete a two-year postdoctoral associateship at the US Air Force Research Laboratory, Space Vehicles Directorate. In 2018 she joined the faculty of Mississippi State University, where her research interests include developing approaches to isobar differentiation using mass spectrometry and applying mass spectrometry to the study of ionic liquids. In 2022 she was named a Cottrell Scholar.Dr. Sheynkman received her BS in Biochemistry from the University of Notre Dame. She has industry experience from working at Gilead Sciences in the Analytical Development department. She then received her PhD from the University of Wisconsin-Madison where she developed integrative proteogenomics methods to discover human proteomic variation. Dr. Sheynkman was a postdoctoral fellow at the Dana-Farber Cancer Institute and Harvard Medical School, where she developed high-throughput functional proteomics approaches to characterize normal and disease protein isoforms. She established her laboratory at the University of Virginia in 2020 and is an Assistant Professor with a primary appointment in The Department of Molecular Physiology and Biological Physics. Her lab aims to accelerate the discovery of clinically actionable protein isoforms by integrating cutting-edge analytical and computational approaches from systems genetics, proteogenomics, and network biology. This precision medicine approach is applied in a disease agnostic manner to elucidate isoform-driven rewiring events in a spectrum of disease from cardiovascular disease to cancer.Stefani Thomas is currently an Assistant Professor in the Department of Laboratory Medicine and Pathology at the University of Minnesota, and she is also the Associate Medical Director of the M Health Fairview University of Minnesota Medical Center West Bank Laboratory. She earned a BA in Biological Sciences with a Minor in Music from Dartmouth College and a PhD in Pharmaceutical Sciences from the University of Southern California. After completing a research postdoctoral fellowship in the lab of Dr. Robert Cotter at Johns Hopkins, Stefani joined the Center for Biomarker Discovery and Translation at Johns Hopkins where she conducted mass spectrometry-based clinical proteomics research under the supervision of Drs. Hui Zhang and Daniel Chan. She then completed a Clinical Chemistry postdoctoral fellowship at Johns Hopkins and earned board certification. The focus of Stefani's research program at the University of Minnesota is the application of mass spectrometry-based clinical proteomics approaches for cancer biomarker development. She has authored >70 publications, she is an Associate Editor of Clinical Proteomics, and her research has been funded by the National Cancer Institute, V Foundation for Cancer Research, American Cancer Society, and the Minnesota Ovarian Cancer Alliance.Mingxun Wang is an Assistant Professor in the Department of Computer Science at the University of California Riverside. His lab develops computational methods to organize, visualize, and analyze small molecule mass spectrometry data. He received his BS summa cum laude in Computer Engineering from the University of Illinois Urbana–Champaign in 2009. He earned his PhD in Computer Science from the University of California San Diego under the supervision of Prof. Nuno Bandeira in 2017. He completed his postdoctoral training in 2022 under the supervision of Prof. Pieter C. Dorrestein at the University of California San Diego.Author InformationClick to copy section linkSection link copied!Corresponding AuthorsErin S. Baker, Email: [email protected]Helen J. Cooper, Email: [email protected]NotesViews expressed in this editorial are those of the authors and not necessarily the views of the ACS.Cited By Click to copy section linkSection link copied!This article has not yet been cited by other publications.Download PDFFiguresReferences Get e-AlertsGet e-AlertsJournal of the American Society for Mass SpectrometryCite this: J. Am. Soc. Mass Spectrom. 2024, 35, 11, 2547–2553Click to copy citationCitation copied!https://doi.org/10.1021/jasms.4c00375Published November 6, 2024 Publication History Received 12 September 2024Published online 6 November 2024Published in issue 6 November 2024Copyright © 2024 American Society for Mass Spectrometry. Published by American Chemical Society. All rights reserved. This publication is available under these Terms of Use. Request reuse permissionsArticle Views-Altmetric-Citations-Learn about these metrics closeArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. 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