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Human CFTR deficient iPSC-macrophages reveal impaired functional and transcriptomic response upon Pseudomonas aeruginosa infection

2024; Frontiers Media; Volume: 15; Linguagem: Inglês

10.3389/fimmu.2024.1397886

1664-3224

Claudio Rodriguez Gonzalez, Débora Basílio-Queirós, Anna‐Lena Neehus, Sylvia Merkert, David Tschritter, Sinem Ünal, Jan Hegermann, Matthias Mörgelin, Jacinta Bustamante, Manuel Nietert, Ulrich Martin, Burkhard Tümmler, Antje Munder, Nico Lachmann,

Single-cell and spatial transcriptomics

Cystic fibrosis (CF) is a hereditary autosomal recessive disease driven by deleterious variants of the CFTR gene, leading, among other symptoms, to increased lung infection susceptibility. Mucus accumulation in the CF lung is, as of yet, considered as one important factor contributing to its colonization by opportunistic pathogens such as