Produção Nacional
Revisado por pares
Evaluation of Myocarditis in Patients With Still Disease: Clinical Findings From the Multicenter International AIDA Network Still Disease Registry
2024; The Journal of Rheumatology Publishing Company Limited; Linguagem: Inglês
10.3899/jrheum.2024-0683
ISSN1499-2752
AutoresPiero Ruscitti, Ilenia Di Cola, Antonio Vitale, Valeria Caggiano, Pierpaolo Palumbo, Ernesto Di Cesare, Jiram Torres‐Ruiz, Guillermo Arturo Guaracha-Basáñez, Eduardo Martín‐Nares, Francesco Ciccia, Daniela Iacono, Flavia Riccio, Maria Cristina Maggio, Samar Tharwat, Soad Hashad, Donato Rigante, Augusta Ortolan, Henrique Ayres Mayrink Giardini, Isabele Parente de Brito Antonelli, Rafael Alves Cordeiro, Roberto Giacomelli, Luca Navarini, Onorina Berardicurti, Alessandro Conforti, Daniela Opriş-Belinski, Jurgen Sota, Carla Gaggiano, Giuseppe Lopalco, Florenzo Iannone, Francesco La Torre, Violetta Mastrorilli, Marcello Govoni, Francesca Ruffilli, Giacomo Emmi, Edoardo Biancalana, Petros P. Sfikakis, Maria G. Tektonidou, José Hernández‐Rodríguez, Verónica Gómez‐Caverzaschi, Özgül Soysal Gündüz, Giovanni Conti, Serena Patroniti, Antonio Gidaro, Arianna Bartoli, Alma Nunzia Olivieri, Maria Francesca Gicchino, Antonio Brucato, Lorenzo Dagna, Alessandro Tomelleri, Corrado Campochiaro, Amato de Paulis, Ilaria Mormile, Francesca Della Casa, Haner Di̇reskeneli̇, Fatma Alıbaz-Öner, Αναστάσιος Καραμανάκος, Aikaterini Dimouli, Gaafar Ragab, Ayman Abdel-Monem Ahmed Mahmoud, Abdurrahman Tufan, Hamit Küçük, R. C. Kardaş, Ezgi Deniz Batu, Seza Özen, Ewa Więsik‐Szewczyk, Andrea Hinojosa‐Azaola, Alberto Balistreri, Claudia Fabiani, Bruno Frediani, Luca Cantarini,
Tópico(s)Transplantation: Methods and Outcomes
ResumoObjective We aimed to (1) evaluate the cardiac involvement, with a focus on myocarditis, in patients with Still disease included in the multicenter Autoinflammatory Disease Alliance (AIDA) Network Still disease registry; and (2) assess the predictive factors for myocarditis by deriving a clinical risk patient profile for this severe manifestation. Methods A multicenter observational study was established, in which consecutive patients with Still disease in the AIDA Network Still disease registry were characterized by cardiac involvement. Cardiac involvement was defined according to the presence of pericarditis, tamponade, myocarditis, and/or aseptic endocarditis. Results In total, 73 patients with Still disease and cardiac involvement were assessed (mean age 36.3 [SD 19.9] years; male sex, 42.5%), out of which 21.9% were children. The most common cardiac manifestation was pericarditis, occurring in 90.4% of patients; patients also presented with myocarditis (26%), and less frequently endocarditis (2.7%) and tamponade (1.4%). In comparing clinical features of patients with myocarditis to those without, significantly increased frequencies of skin rash and pleuritis, as well as higher systemic scores, were seen. Further, a higher mortality rate was shown in patients with myocarditis. In regression models, skin rash and the systemic score independently predicted the myocarditis. Conclusion The characteristics of patients with Still disease and cardiac involvement were assessed in the AIDA Network. The most common feature was the pericarditis, but a more severe clinical picture was also reported in patients with myocarditis. The latter was associated with increased mortality rate and higher systemic score, identifying patients who should be carefully managed.
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