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Effects of COVID-19 virus-like particles on the behavioral and cognitive performance of human apolipoprotein E targeted replacement mice

2024; Frontiers Media; Volume: 15; Linguagem: Inglês

10.3389/fimmu.2024.1473366

1664-3224

Abigail O’Niel, Alexandra Pederson, Elizabeth Saltontall, Kayla X. Nguyen, Messy Hannear de Andrade Pantoja, Mitali Chaudhari, Phoebe Sandholm, Eui-Sung Yoon, Hooi-Ling Harrison, Sydney Weber Boutros, Alec J. Hirsch, Jacob Raber,

Apelin-related biomedical research

The effects of viral infections might be apolipoprotein E (apoE) isoform-dependent. In humans, there are three major apoE isoforms, E2, E3, and E4. E4 is associated with the enhanced entry of several viruses into the brain and their disease progression. A concern of infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the development of post-acute COVID-19 syndrome, also known as long COVID. Genetic risk factors for developing long COVID were reported.