Portal de Periódicos da CAPES

Unveiling the Digital Evolution of Molecular Tumor Boards

2024; Adis, Springer Healthcare; Linguagem: Inglês

10.1007/s11523-024-01109-1

1776-260X

Sebastian Lutz, Armando D’Angelo, Sonja Hammerl, Maximilian Schmutz, Rainer Claus, N. Fischer, Frank Krämer, Zaynab Hammoud,

Gene expression and cancer classification

Molecular tumor boards (MTB) are interdisciplinary conferences involving various experts discussing patients with advanced tumors, to derive individualized treatment suggestions based on molecular variants. These discussions involve using heterogeneous internal data, such as patient clinical data, but also external resources such as knowledge databases for annotations and search for relevant clinical studies. This imposes a certain level of complexity that requires huge effort to homogenize the data and use it in a speedy manner to reach the needed treatment. For this purpose, most institutions involving an MTB are heading toward automation and digitalization of the process, hence reducing manual work requiring human intervention and subsequently time in deriving personalized treatment suggestions. The tools are also used to better visualize the patient's data, which allows a refined overview for the board members. In this paper, we present the results of our thorough literature research about MTBs, their process, the most common knowledge bases, and tools used to support this decision-making process.