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The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant Therapy

2025; Kazimierz Wielki University in Bydgoszcz; Volume: 37; Linguagem: Inglês

10.12775/qs.2025.37.57174

2450-3118

Mateusz Górski, Adrianna Załęska, Mateusz Bychowski, Julia Kwaśna, Izabela Kaźmierczyk, Kacper Lenart, Michał Homza, Natalia Zakrzewska, Szymon Bednarek, Joanna Kulicka,

Biochemical effects in animals

Background: Coenzyme Q10 (CoQ10), a key component of mitochondrial energy production and a potent antioxidant, plays an essential role in addressing oxidative stress and mitochondrial dysfunction. Its applications span cardiovascular health, infectious diseases, neurological conditions, reproductive health, and fatigue management. However, gaps remain in understanding its optimal dosing, long-term impact, and efficacy across diverse health conditions. Methods: This review synthesized findings from clinical trials, meta-analyses, and observational studies. A systematic search of PubMed and ScienceDirect was conducted, selecting studies based on methodological rigor and relevance to CoQ10’s mechanisms, efficacy, and safety. Results: CoQ10 supplementation reduced cardiovascular mortality, alleviated migraine symptoms, improved mitochondrial function, and decreased oxidative stress. Promising but inconclusive evidence supports its role in managing statin-induced myopathy and enhancing reproductive outcomes. CoQ10 was consistently shown to be safe and well-tolerated. Conclusion: CoQ10 demonstrates significant therapeutic potential across several health conditions. Its antioxidant and bioenergetic benefits are well-documented, but further research is needed to refine dosing strategies and evaluate long-term effects. CoQ10 remains a promising complementary therapy for modern health challenges.