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Cancer Research in the Age of Spatial Omics: Lessons from IMAXT

2025; American Association for Cancer Research; Volume: 15; Issue: 1 Linguagem: Inglês

10.1158/2159-8290.cd-24-1686

2159-8290

Dario Bressan, N. A. Walton, Gregory J. Hannon, Mohammad Al Sa’d, Bruno Albuquerque, H. Raza Ali, Martina Alini, Samuel Aparício, Heather Ashmore, Thomas J. Ashmore, Vinci Au, Shankar Balasubramanian, Caroline Baril, Giorgia Battistoni, Sean Beatty, Robby Becker, Bernd Bodenmiller, Alina Bollhagen, Carla Boquetale, Edward S. Boyden, Dario Bressan, Alejandra Bruna, Marcel Burger, Carlos Caldas, Maurizio Callari, Ian G. Cannell, Hannah Casbolt, Nick Chornay, Nikki Coutts, A. Dariush, Lauren Deighton, Khanh N. Dinh, Natalie Duncan, Yaniv Eyal-Lubling, Ilaria Falciatori, Jean Fan, Atefeh Fatemi, Debarati Ghosh, Carlos González‐Fernández, E. A. González-Solares, Wendy Greenwood, Flaminia Grimaldi, Gregory J. Hannon, Owen Harris, Suvi Harris, Nicole Hemmer, Kui Hua, Muhammad Irfan, Cristina Jauset, Johanna A. Joyce, Tatjana Kovačević, Laura Kuett, Russell Kunes, A. Yoldaş, Daniel Lai, Emma Laks, Hsuan Lee, Max Lee, Giulia Lerda, Yangguang Li, J. Lovell, Yangning Lu, John C. Marioni, Andrew McPherson, Neil S. Millar, Alireza Molaeinezhad, Claire M. Mulvey, Natasha Narayanan, João C. F. Nogueira, Fiona Nugent, Ciara H. O’Flanagan, Marta Ribes, Isabella Pearsall, Sarah M. Pearsall, Brett Pryor, Fatime Qosaj, Clare A. Rebbeck, Andrew Roth, Oscar M. Rueda, Teresa Ruíz, Kirsty Sawicka, Leonardo A. Sepúlveda, Sohrab P. Shah, Abigail Shea, Anubhav Sinha, Austin Smith, Leigh M. Smith, Simon Tavaré, Ignacio Vázquez-Garćıa, Sara Lisa Vogl, N. A. Walton, Spencer S. Watson, Joanna Weselak, Tristan Whitmarsh, Sophia A. Wild, Elena Williams, Jonas Windhager, Chenglong Xia, Chee Ying Sia, Chi Zhang, Ruihan Zhang, Pu Zheng, Xiaowei Zhuang,

Cell Image Analysis Techniques

Summary: The Imaging and Molecular Annotation of Xenografts and Tumors Cancer Grand Challenges team was set up with the objective of developing the “next generation” of pathology and cancer research by using a combination of single-cell and spatial omics tools to produce 3D molecularly annotated maps of tumors. Its activities overlapped, and in some cases catalyzed, a spatial revolution in biology that saw new technologies being deployed to investigate the roles of tumor heterogeneity and of the tumor micro-environment. See related article by Stratton et al., p. 22 See related article by Bhattacharjee et al., p. 28 See related article by Goodwin et al., p. 34