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IMPACT OF TRICHOMONAS VAGINALIS AND HPV CO-INFECTION ON THE RISK OF CERVICAL INTRAEPITHELIAL NEOPLASIA: A NARRATIVE REVIEW OF THE LITERATURE

2025; Volume: 5; Issue: 4 Linguagem: Inglês

10.22533/at.ed.159542514015

2764-0159

Jenniffer Mileny Jacob, Maria Julia Santana Santos Cotta, Marcela Calio Martin Boso, Ana Bárbara Suckow Landim, Mariana Cardoso Malaman, Gabriel Vinícius Souza de Vasconcelos, Fernanda Victória de Moro Loures, Bruna Bevilacqua Armellin, George Dantas Azevedo, A.A. Silva, Marcella Camilly Vale Antunes, Neidejany de Assunção do Sacramento,

Genital Health and Disease

Objective: To analyze the association between co-infection with Trichomonas vaginalis (TV) and the increased risk of cervical intraepithelial neoplasia (CIN) in women infected with human papillomavirus (HPV), through a narrative review of the literature.Method: This is a literature review study carried out on the PubMed database, using the search terms "Trichomonas vaginalis", "risk", "HPV" and their combinations.Twelve articles were selected for detailed analysis.Review: The findings suggest that co-infection with TV and HPV, especially the HPV-16 subtype, is associated with an increased risk of CIN.In a study of 5,683 patients, an increased risk of CIN was identified in VT and HPV-16 co-infections, while another smaller study did not confirm this relationship (Hu et al., 2021).VT infection promotes changes in the vaginal microbiota, facilitating the persistence of HPV and making it more difficult to eliminate, which can aggravate the cervical lesions observed in cytological exams.Final considerations: Co-infection with Trichomonas vaginalis and HPV represents a significant risk factor for the development of CIN, since the chronic inflammation and epithelial damage caused by VT, combined with the persistence of HPV, weaken the immune system, favoring the development of precancerous lesions.These findings reinforce the need for rigorous monitoring and effective preventive approaches for women at risk of co-infection.