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Evidence for the Association between Blood Prolactin and Androgen Receptors in BPH

1985; Lippincott Williams & Wilkins; Volume: 133; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(17)49168-3

1527-3792

Sule Odoma, G. D. CHISHOLM, Keith Nicol, Fouad K. Habib,

Thyroid Disorders and Treatments

No AccessJournal of Urology1 Apr 1985Evidence for the Association between Blood Prolactin and Androgen Receptors in BPH Sule Odoma, Geoffrey D. Chisholm, Keith Nicol, and Fouad K. Habib Sule OdomaSule Odoma , Geoffrey D. ChisholmGeoffrey D. Chisholm , Keith NicolKeith Nicol , and Fouad K. HabibFouad K. Habib View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)49168-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The purpose of this study was to investigate the relationship between prostatic androgen receptors and plasma prolactin and testosterone in patients with benign prostatic hyperplasia. Cytosolic and KCl extractable nuclear androgen receptors were measured in 22 patients and these were in turn correlated to the hormone concentrations in blood specimens taken on the morning before the day of operation. The mean ± S.E.M. concentrations of cytoplasmic androgen receptors, KCl extractable nuclear androgen receptors, plasma testosterone and plasma prolactin were respectively 115 ± 18fmoles/gm. tissue, 198 ± 40fmoles/gm. tissue, 15.6 ± 1.2nmol./l. and 128 ± 17mU/l. Plasma prolactin was highly correlated with cytosolic androgen receptors (r = 0.784, p 0.05; no. = 15). However, when the androgen receptor levels were expressed as fmoles/mg. protein both cytosolic and nuclear levels were proportional to plasma prolactin (p <0.01 and p <0.02 for both the cytosolic and nuclear receptors respectively; no. = 15). There was no correlation between either cytosolic and nuclear androgen receptors and plasma testosterone levels. The results suggest that plasma prolactin may be involved in the regulation of androgen receptor content in the benign prostate. © 1985 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 133Issue 4April 1985Page: 717-720 Advertisement Copyright & Permissions© 1985 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Sule Odoma Supported by the Institute of Health, Ahmadu Bello University, Zaria, Nigeria. More articles by this author Geoffrey D. Chisholm More articles by this author Keith Nicol More articles by this author Fouad K. Habib More articles by this author Expand All Advertisement PDF downloadLoading ...