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Geranyl N -Dimethylallylanthranilate, a New Compound from Esenbeckia yaaxhokob

2004; Thieme Medical Publishers (Germany); Volume: 70; Issue: 1 Linguagem: Inglês

10.1055/s-2004-815465

1439-0221

A. Berenice Aguilar‐Guadarrama, Marı́a Yolanda Rios,

Essential Oils and Antimicrobial Activity

Through a bioactivity-guided fractionation from the acetone extract of the leaves from Esenbeckia yaaxhokob geranyl N-dimethylallylanthranilate ( 1), the first natural N- and O-prenylated anthranilate, was isolated in addition of the known natural products caryophyllene beta-oxide, caryolane-5beta,9beta-diol, spathulenol ( 2), friedeline, friedelanol, decaprenol, flindersiamine ( 3) and beta-sitosterol. The antimicrobial activities of the extract, fractions and pure compounds were evaluated against two Gram (+) and four Gram (-) bacteria. Compounds 1 and 2 exhibited moderated antimicrobial activity against Staphyloccocus aureus, while 3 was active against S. aureus and Streptococcus faecalis.