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Cure of duodenal ulcer after eradication of Helicobacter pylori

1990; Wiley; Volume: 153; Issue: 3 Linguagem: Inglês

10.5694/j.1326-5377.1990.tb136833.x

1326-5377

Laura L. George, Thomas J. Borody, Peter Andrews, Michele Devine, D. Moore‐Jones, Mary N. Walton, S. Brandi,

Gastroesophageal reflux and treatments

Medical Journal of AustraliaVolume 153, Issue 3 p. 145-149 Original Articles Cure of duodenal ulcer after eradication of Helicobacter pylori Laura L George MD, Laura L George MD Research Fellow Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this authorThomas J Borody MD, FRACP, Corresponding Author Thomas J Borody MD, FRACP Director n/a@dne.dne Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046 Reprints: Dr Thomas J Borody.Search for more papers by this authorPeter Andrews MB BS, Peter Andrews MB BS Research Associate Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this authorMichele Devine RN, Michele Devine RN Trained Nurse Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this authorDeborah Moore-Jones EN, Deborah Moore-Jones EN Trial Coordinator Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this authorMary Walton RN, Mary Walton RN Trained Nurse Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this authorSusan Brandi MB BS, Susan Brandi MB BS Research Associate Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this author Laura L George MD, Laura L George MD Research Fellow Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this authorThomas J Borody MD, FRACP, Corresponding Author Thomas J Borody MD, FRACP Director n/a@dne.dne Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046 Reprints: Dr Thomas J Borody.Search for more papers by this authorPeter Andrews MB BS, Peter Andrews MB BS Research Associate Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this authorMichele Devine RN, Michele Devine RN Trained Nurse Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this authorDeborah Moore-Jones EN, Deborah Moore-Jones EN Trial Coordinator Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this authorMary Walton RN, Mary Walton RN Trained Nurse Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this authorSusan Brandi MB BS, Susan Brandi MB BS Research Associate Centre for Digestive Diseases, 144 Great North Road, Five Dock, NSW, 2046Search for more papers by this author First published: 01 August 1990 https://doi.org/10.5694/j.1326-5377.1990.tb136833.xCitations: 159AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Eighty-two patients, whose duodenal ulcers were recurrent or resistant to H,-receptor antagonist therapy, were entered in a treatment protocol of ranitidine followed by a four-week “triple therapy” course to eradicate Helicobacter pylori(HP) infection. The triple therapy consisted of colloidal bismuth subcitrate, tetracycline and metronidazole. Duodenal ulcer healed in all 78 patients available for endoscopy and H. pylori infection was shown to be eliminated in 75 patients (96%) at rebiopsy four weeks after cessation of therapy. In these 75 remaining patients the relapse rates for H. pyloriinfection and duodenal ulcer were studied endoscopically, yearly and at any recurrence of symptoms. At Year 1, 71 of 73 patients remained free of H. pyloriinfection (HP-negative) and duodenal ulcer. The corresponding figures subsequently were: Year 2, 57/57; Year 3, 34/34; Year 4, 15/15. No duodenal ulcers recurred in HP-negative patients who were followed for up to four years. Two patients of the original cohort of 75 HP-negative patients were HP-positive with endoscopic duodenitis at 12 months, and one at 36 months, but all were without reulceration. Distorted duodenal caps gradually returned to near-normal appearance in 80% of patients by two years. From this four-year follow-up study we conclude that duodenal ulcer disease will not recur provided the patient remains free of H. pylori. Citing Literature Volume153, Issue3August 1990Pages 145-149 This article also appears in:MJA Backfile Highlights RelatedInformation