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Implications of immunomodulant therapy in Alzheimer’s disease

1988; Linguagem: Inglês

10.1007/978-3-0348-9154-7_2

Vijendra K. Singh, H. Hugh Fudenberg,

Neurological Disorders and Treatments

Alzheimer's Disease (AD) is a degenerative disorder of the central nervous system (CNS), generally characterized by the impairment of memory (especially, the memory of recent events), intellect and cognitive functions in elderly individuals. The deterioration of these mental activities is attributed to the degeneration of nerve cells specifically localized in certain brain regions, e.g. basal forebrain, neocortex, hippocampus and amygdala [1–3]. About 6 to 8 % of individuals past the age of 60 years suffer from senile dementia and approximately 56 % of them are known to be afflicted with AD.