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Doxepin and cimetidine in the treatment of duodenal ulcer: an open clinical and endoscopic study.

1982; National Institutes of Health; Volume: 43; Issue: 8 Pt 2 Linguagem: Inglês

T. E. Ruud, Geir Hoff, Michaela Tonder, O Holter,

Helicobacter pylori-related gastroenterology studies

In an open clinical endoscopic study, 50 patients with duodenal ulcer showed no significant difference in ulcer healing during a 6-week treatment period with doxepin HCl (50 mg h.s.) versus cimetidine (1000 mg/day in divided doses). Possible tricyclic mechanisms of action in the treatment of peptic ulcer, e.g., histamine H2 blockade, are discussed.