HIV type 1 integrase inhibitors: from basic research to clinical implications.
2008; National Institutes of Health; Volume: 10; Issue: 3 Linguagem: Inglês
Autores
Oyebisi Jegede, John Babu, Roberto Di Santo, Damian J McColl, Jan Weber, Miguel E. Quiñones‐Mateu,
Tópico(s)Biochemical and Molecular Research
ResumoSimilar to other retroviruses, productive infection with HIV-1 requires three key steps in the viral replication: (i) reverse transcription of viral genomic RNA into viral cDNA by the viral reverse transcriptase; (ii) integration of viral cDNA into host cell genome using the viral integrase; and (iii) cleavage of newly synthesized viral polypeptide by the viral protease into individual viral proteins during new virion assembly. Following their discovery, all three viral enzymes were considered as targets for antiretroviral drugs. However, while multiple reverse transcriptase and protease inhibitors have been used for more than 12 years to treat HIV-infected individuals, only recently has the viral integrase enzyme emerged as an alternative, clinically validated target to block HIV-1 replication. Here we review the biology of HIV-1 integration, the mechanisms of action and development of resistance to integrase inhibitors, and the latest data on the most recent clinical trials involving this promising, novel class of antiretroviral drugs.
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