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BIBTEX RIS

Structures of diphospho- myo -inositol pentakisphosphate and bisdiphospho- myo -inositol tetrakisphosphate from Dictyostelium resolved by NMR analysis

1996; Portland Press; Volume: 315; Issue: 3 Linguagem: Inglês

10.1042/bj3150715

ISSN

1470-8728

Autores

Tim Laußmann, R. Eujen, C. M. WEISSHUHN, Ulrich Thiel, Günter Vogel,

Tópico(s)

Nuclear Structure and Function

Resumo

Diphospho-myo-inositol phosphates (PP-InsP5 and bis-PP-InsP4) were isolated from Dictyostelium in order to clarify the precise positional isomerism by two-dimensional 1H/31P-NMR analysis. The diphosphorylated inositol phosphates are 4-PP-Ins(1,2,3,5,6)P5 and 4,5-bis-PP-Ins(1,2,3,6)P4 or their corresponding enantiomers. The vicinal arrangement of the diphospho groups with its steric and electrostatic constraints possibly qualifies bis-PP-InsP4 as a metabolite with high phosphate-group-transfer potential in phosphotransferase reactions.

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