Exercise training modulates right ventricular function and remodeling in experimental pulmonary arterial hypertension
2012; Wiley; Volume: 26; Issue: S1 Linguagem: Inglês
10.1096/fasebj.26.1_supplement.872.8
ISSN1530-6860
AutoresDaniel Moreira‐Gonçalves, Hélder Fonseca, Rita Ferreira, Ana Isabel Padrão, Francisco Vasques‐Nóvoa, Sara Vieira, Manuel P. Pinto, Nádia Gonçalves, Marina Dias‐Neto, Rodney Coelho da Paixão, Francisco Amado, José Alberto Duarte, Adelino Leite‐Moreira, Tiago Henriques‐Coelho,
Tópico(s)Cardiovascular Function and Risk Factors
ResumoRight ventricle failure (RVF) is a major determinant of survival in pulmonary arterial hypertension (PAH). Exercise training was shown to be beneficial in left ventricle failure but its impact on RVF remains unknown. We investigated whether exercise training modulates the right ventricular response to chronic pressure overload in monocrotaline (MCT) model of PAH. Male Wistar rats were submitted to normal cage activity (SED+MCT) or to treadmill exercise training (EXtreat+MCT) after the establishment of RV pressure overload induced by MCT (60 mg/kg). Exercise training attenuated cardiac hypertrophy, improved cardiac function and survival. Exercise training normalized RV SERCA2a protein levels, beta/alpha MHC isoform, ET‐1 and VEGF mRNA, cardiac fibrosis and inflammation. Mitochondrial function was preserved and was accompanied by reduced oxidative damage. These data suggest that exercise training is cardioprotective in RVF induced by experimental PAH and provide some insights about the putative underlying cardioprotective mechanisms.
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