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Chorioretinitis with a combined defect in T and B lymphocytes and granulocytes

1980; Elsevier BV; Volume: 68; Issue: 6 Linguagem: Inglês

10.1016/0002-9343(80)90230-2

1555-7162

Catherine U. Kyong, Gregory B. Wilson, H. Hugh Fudenberg, J M Goust, P. M. Richardson, John Eckerd,

Neutrophil, Myeloperoxidase and Oxidative Mechanisms

A patient with immune deficiency, recurrent pyogenic infections and active chorioretinitis is described; in addition to agammaglobulinemia, both quantitative and qualitative T-cell deficiencies were documented. Furthermore, the patient's granulocytes (polymorphonuclear leukocytes), although normal in their bactericidal capacity for Staphylococcus, responded poorly to both leukocyte migration inhibition factor and neutrophil immobilizing factor obtained from normal cells. The immunologic features of this patient appear to comprise a new syndrome. Remarkable diminution of the ocular lesions and increased visual acuity occurred within two months after the initiation of therapy with dialyzable leukocyte extracts (transfer factor). Concurrent testing of the patient's cell-mediated immunity showed increased numbers of circulating T lymphocytes and improved T-cell function following dialyzable leukocyte extract [DLE] therapy. The dramatic clinical results indicate that similar therapy may prove to be beneficial in other patients with chorioretinitis and T-cell deficiency.