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Heterogeneity of alpha-1 Adrenergic Receptors

1987; Humana Press; Linguagem: Inglês

10.1007/978-1-4612-4582-7_8

2524-6488

J. Paul Hieble, William D. Matthews, Robert M. DeMarinis, Robert Ruffolo,

Neuropeptides and Animal Physiology

The alpha-1 adrenergic receptor, located postjunctionally on smooth muscle and other tissues, has been studied for decades, although not recognized as a specific subtype. Until recently, alpha-adrenergic receptors were not subdivided, and the alpha-adrenergic receptor-mediated responses commonly measured, such as contraction of smooth muscle in vitro and elevation of blood pressure in the intact animal, resulted from activation of receptors now designated as alpha-1.