The Natural Products Chemistry of Cyanobacteria
2010; Elsevier BV; Linguagem: Inglês
10.1016/b978-008045382-8.00041-1
AutoresKevin Tidgewell, Benjamin R. Clark, William H. Gerwick,
Tópico(s)Algal biology and biofuel production
ResumoThe natural products of cyanobacteria are some of the most structurally intriguing and biologically active products in the natural world. They are largely formed by combining polyketide and amino acid building blocks to produce a wide array of different lipopeptides. However, there are some intriguing metabolites produced by these organisms of a purely fatty acid, terpene, carbohydrate, peptide, or polyketide nature as well. We initiate this chapter by a global tallying of the marine genera and species of cyanobacteria that have yielded secondary metabolites as well as their molecular weight distribution. Next, we discuss our analysis of all cyanobacterial metabolites, of both marine and freshwater origins, in terms of their fundamental class of natural product, their component pieces with special focus on amino acids, and the degree and nature of secondary tailoring reactions (e.g., glycosylation, halogenation, and methylation). Following this overview of the metabolic trends of cyanobacterial natural products, we discuss specific examples in the various structural classes. Our goal in this later section of the chapter is to showcase and discuss the structures, biosynthesis, and biological properties of prominent representative compounds, which illustrate the trends discussed in the preceding overview section.
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