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Analysis of the HUMTH01 Allele Frequencies in the Spanish Population

1994; Wiley; Volume: 39; Issue: 5 Linguagem: Inglês

10.1520/jfs13712j

1556-4029

José A. Lorente, Miguel Lorente Acosta, Bruce Budowle, MR Wilson, E. Villanueva,

Molecular Biology Techniques and Applications

Genetic marker typing based on DNA amplification by the polymerase chain reaction (PCR) increasingly is being employed in forensic casework and for paternity testing. The allele frequencies were determined using PCR for 120 unrelated Spanish Caucasians for the locus HUMTHOH1. Six alleles were observed, with frequencies ranging from 0.013 (allele 11) to 0.254 (allele 10). The observed heterozygosity was 75.8%, and the power of discrimination is 0.92. The genotype distribution meets Hardy-Weinberg expectations.