Portal de Periódicos da CAPES

An Experimental Basis for Intravenous Vaccine Therapy in Chronic Arthritis With a Summary of Results Obtained in Patients

1932; American College of Physicians; Volume: 5; Issue: 12 Linguagem: Inglês

10.7326/0003-4819-5-12-1447

1539-3704

B. J. Clawson, MACNIDER WETHERBY,

Tuberculosis Research and Epidemiology

Article1 June 1932An Experimental Basis for Intravenous Vaccine Therapy in Chronic Arthritis With a Summary of Results Obtained in PatientsB. J. CLAWSON, M.D., M. WETHERBY, M.D.B. J. CLAWSON, M.D.Search for more papers by this author, M. WETHERBY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-12-1447 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe factors considered as a basis for intravenous streptococcic vaccination reported in this paper are (1) etiology and (2) a method of vaccination which will not produce hypersensitiveness (allergy) but will desensitize patients already hypersensitive and will produce a high degree of protective immunity.ETIOLOGYThe belief that most cases of chronic arthritis are infectious in origin is quite generally accepted. The exact infectious agent and the manner and the form in which the agent finds its way into the joints are not so generally agreed upon. Some people believe that there is a direct infection of the joint by...References1 MOONEDWARDS VCSH: Results of blood cultures in rheumatoid arthritis, Jr. Infect. Dis., 1917, xxi, 154. CrossrefGoogle Scholar2 RICHARDS JH: Bacteriologic studies in chronic arthritis and chorea, Jr. Bact., 1920, v, 511. CrossrefGoogle Scholar3 HADJOPOULOSBURBANK LGR: A preliminary study bearing on the causative factors of multiple infectious arthritis, Jr. Bone and Joint Surg., 1927, ix, 278. Google Scholar4 CECILNICHOLLSSTAINSBY RLEEWJ: The bacteriology of the blood and joints in chronic infectious arthritis, Arch. Int. Med., 1929, xliii, 571. CrossrefGoogle Scholar5 KLUGH GF: Streptococci from blood cultures in arthritis, So. Med. Jr., 1931, xxiv, 706. CrossrefGoogle Scholar6 DAWSONOLMSTEADBOOTS MHMRH: Bacteriological investigation on blood, synovial fluid and subcutaneous nodules in rheumatoid arthritis, Proc. Soc. Exper. Biol. and Med., 1931, xxviii, 419. CrossrefGoogle Scholar7 GRAYGOWEN JWCH: The rôle of streptococci in arthritis deformans, Am. Jr. Med. Sci., 1931, clxxxii, 682. CrossrefGoogle Scholar8 WETHERBYCLAWSON MBJ: A study of chronic arthritis with special reference to intravenous vaccine therapy, Arch. Int. Med., 1932, xlix, 303-320. CrossrefGoogle Scholar9 BILLINGSCOLEMANHIBBS FGHWG: Chronic infectious arthritis, Jr. Am. Med. Assoc., 1922, lxxviii, 1097. Google Scholar10 FORKNERSHANDSPOSTON CEARMA: Synovial fluids in chronic arthritis, Arch. Int. Med., 1928, xlii, 675. CrossrefGoogle Scholar11 SHANDS AR: Personal communication cited by FORKNER, C. E.: The synovial fluid in health and disease with special reference to arthritis, Jr. Lab. and Clin. Med., 1930, xv, 1199. Google Scholar12 CECILNICHOLLSSTAINSBY RLEEWJ: Bacteriology of blood and joints in chronic infectious arthritis, Proc. Soc. Exper. Biol. and Med., 1928, xxiv, 6. CrossrefGoogle Scholar13 POYNTONPAINE FJA: The etiology of rheumatic fever, Lancet, 1900, ii, 861-869. CrossrefGoogle Scholar14 MARGOLISDORSEY HMGH: Chronic arthritis: bacteriology of affected tissues, Arch. Int. Med., 1930, xlvi, 121. CrossrefGoogle Scholar15 ROSENOW EC: The newer bacteriology of various infections as determined by special methods, Jr. Am. Med. Assoc., 1914, lxiii, 903. CrossrefGoogle Scholar16 BAER WS: Discussion of paper by Gibson, Jr. Bone and Joint Surg., 1928, x, 753. Google Scholar17 POSTON MA: Gland cultures in infectious arthritis, Jr. Am. Med. Assoc., 1929, xciii, 692. CrossrefGoogle Scholar18 BIRKHAUG KE: Skin hypersensitiveness of patients with rheumatic fever and chronic arthritides to filtrates, autolysates, and bacterial suspensions of streptococci, Jr. Infect. Dis., 1929, xliv, 363. CrossrefGoogle Scholar19 NICHOLLSSTAINSBY EEWJ: Streptococcic agglutinins in chronic infectious arthritis, Jr. Clin. Invest., 1931, x, 323. CrossrefGoogle Scholar20 NICHOLSRICHARDSON EHFL: Arthritis deformans, Jr. Med. Res., 1909, xxi, 149. Google Scholar21 SWIFT HF: Pathogenesis of rheumatism, Jr. Exper. Med., 1924, xxxix, 497. CrossrefGoogle Scholar22 COATESCOOMBS VCF: Observations on the rheumatic nodule, Arch. Dis. Child., 1926, i, 183. Google Scholar23 DERICKHITCHCOCKSWIFT CLCHHF: Reactions of rabbits to non-hemolytic streptococci: study of modes of sensitization, Jr. Exper. Med., 1931, lii, 1. Google Scholar24 SUTLIFFRHOADES WDDR: The pneumococcidal power of whole blood, Jr. Clin. Invest., 1930, ix, 55. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minn.*Presented at the San Francisco meeting of the American College of Physicians, April 6, 1932.†From the Departments of Pathology and Medicine of the University of Minnesota. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAllergic relations of normal and abnormal floras of the intestine 1 June 1932Volume 5, Issue 12Page: 1447-1461KeywordsAllergy and immunologyArthritisEtiologyImmunityVaccines ePublished: 1 December 2008 Issue Published: 1 June 1932 PDF downloadLoading ...