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Wnt-pathway activation in intestinal-type sinonasal adenocarcinoma.

2011; European Rhinologic Society; Volume: 49; Issue: 5 Linguagem: Inglês

10.4193/rhino.11.037

2589-0085

Juan Pablo Díaz‐Molina, José Luís Llorente, Blanca Vivanco, Pablo Martínez‐Camblor, Manuel Florentino Fresno, Jhudit Pérez‐Escuredo, César Álvarez‐Marcos, Mario Hermsen,

Salivary Gland Tumors Diagnosis and Treatment

Intestinal-type sinonasal adenocarcinoma (ITAC) is an epithelial cancer of the sinonasal sinuses that shows histological similarity to colorectal cancer (CRC) and share chronic inflammation as a possible etiological factor. The Wnt-pathway is one of the most important tumourigenic pathways in CRC. The aim of this study was to investigate if the Wnt-pathway is activated in ITAC.Protein expression profiles of E-cadherin, β-catenin, c-myc and cyclin D1 were analysed by immunohistochemistry in 83 samples of ITAC, organized into tissue microarray blocks.Nuclear β-catenin expression was observed in 31% of the cases and was twice as frequent in papillary/colonic ITAC compared to solid/mucinous subtypes. Loss of membranous β-catenin staining occurred in 24% and loss of membranous E-cadherin in 6% of the cases and this was more prominent in mucinous types. Strong c-myc and cyclin D1 expression was observed in 30% and 4% of the cases, respectively. Nuclear β-catenin expression was significantly related to poor clinical outcome, independent from established factors as tumour stage and histological type.The presence of nuclear β-catenin in 31% of patients with ITACs indicated that in a subset of patients, the Wnt-pathway is active and conveys a worse prognosis.