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Biopsy after External Beam Radiation Therapy for Adenocarcinoma of the Prostate: Correlation with Original Histological Grade and Current Prostate Specific Antigen Levels

1991; Lippincott Williams & Wilkins; Volume: 146; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(17)38077-1

1527-3792

Thomas Dugan, William U. Shipley, Robert H. Young, Lynn Verhey, Alex F. Althausen, Niall M. Heney, Patricia L. McManus, Edward Abraham,

Urologic and reproductive health conditions

No AccessJournal of Urology1 Nov 1991Biopsy after External Beam Radiation Therapy for Adenocarcinoma of the Prostate: Correlation with Original Histological Grade and Current Prostate Specific Antigen Levels Thomas C. Dugan, William U. Shipley, Robert H. Young, Lynn J. Verhey, Alex F. Althausen, Niall M. Heney, Patricia L. McManus, and Edward H. Abraham Thomas C. DuganThomas C. Dugan More articles by this author , William U. ShipleyWilliam U. Shipley More articles by this author , Robert H. YoungRobert H. Young More articles by this author , Lynn J. VerheyLynn J. Verhey More articles by this author , Alex F. AlthausenAlex F. Althausen More articles by this author , Niall M. HeneyNiall M. Heney More articles by this author , Patricia L. McManusPatricia L. McManus More articles by this author , and Edward H. AbrahamEdward H. Abraham More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)38077-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We obtained post-irradiation biopsies in 37 men with initially stage T3 prostatic adenocarcinoma treated by external beam radiotherapy. Eligibility for post-irradiation biopsy included no clinical local failure, interval since treatment of 24 months or more and no endocrine therapy. Of the 37 patients 23 (62%) had negative biopsies while 14 (38%) had positive biopsies. Of 23 patients whose original cancer was well or moderately differentiated 18 (78%) had negative biopsies, compared to only 5 of 14 (36%) of those with poorly differentiated cancer (p <0.03). Among 19 patients whose current serum prostate specific antigen (PSA) value is less than 2.5ng./ml. 15 (79%) had negative biopsies, compared to only 4 of 14 (29%) with a PSA level of greater than 2.5ng./ml. (p <0.02). These results strongly suggest that there is a low probability of positive post-irradiation biopsy regardless of its significance in men with a normal prostate by palpation and a normal serum PSA value. However, short followup since biopsy precludes analysis of the predictive value of postirradiation biopsy on long-term local and distant disease status. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByTaneja S (2018) Re: Importance of Local Control in Early-Stage Prostate Cancer: Outcomes of Patients with Positive Post-Radiation Therapy Biopsy Results Treated in RTOG 9408Journal of Urology, VOL. 195, NO. 2, (351-352), Online publication date: 1-Feb-2016.Rosser C, Chichakli R, Levy L, Kuban D, Smith L and Pisters L (2018) Biochemical Disease-Free Survival in Men Younger Than 60 Years With Prostate Cancer Treated With External Beam RadiationJournal of Urology, VOL. 168, NO. 2, (536-541), Online publication date: 1-Aug-2002.Vicini F, Horwitz E, Gonzalez J and Martinez A (2018) Treatment Options for Localized Prostate Cancer Based on Pretreatment Serum Prostate Specific Antigen LevelsJournal of Urology, VOL. 158, NO. 2, (319-325), Online publication date: 1-Aug-1997.Rosenzweig K, Morgan W, Lytton B and Peschel R (2018) Prostate Specific Antigen Following Radiotherapy for Local Prostate CancerJournal of Urology, VOL. 153, NO. 5, (1561-1564), Online publication date: 1-May-1995.Rogers E, Ohori M, Kassabian V, Wheeler T and Scardino P (2018) Salvage Radical Prostatectomy: Outcome Measured by Serum Prostate Specific Antigen LevelsJournal of Urology, VOL. 153, NO. 1, (104-110), Online publication date: 1-Jan-1995.Zietman A, Shipley W and Coen J (2018) Radical Prostatectomy and Radical Radiation Therapy for Clinical Stages T1 to 2 Adenocarcinoma of the Prostate: New Insights into Outcome from Repeat Biopsy and Prostate Specific Antigen FollowupJournal of Urology, VOL. 152, NO. 5 Part 2, (1806-1812), Online publication date: 1-Nov-1994.Willett C, Zietman A, Shipley W and Coen J (2018) The Effect of Pelvic Radiation Therapy on Serum Levels of Prostate Specific AntigenJournal of Urology, VOL. 151, NO. 6, (1579-1581), Online publication date: 1-Jun-1994.Shipley W (2018) Radiation TherapyJournal of Urology, VOL. 147, NO. 3 Part 2, (929-930), Online publication date: 1-Mar-1992. Volume 146Issue 5November 1991Page: 1313-1316 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.Keywordsprostatic neoplasmsbiopsyradiotherapyantigens, neoplasmadenocarcinomaMetricsAuthor Information Thomas C. Dugan More articles by this author William U. Shipley More articles by this author Robert H. Young More articles by this author Lynn J. Verhey More articles by this author Alex F. Althausen More articles by this author Niall M. Heney More articles by this author Patricia L. McManus More articles by this author Edward H. Abraham More articles by this author Expand All Advertisement Loading ...