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Current and Future Roles of Adjuvant Endocrine Therapy in the Management of Early Carcinoma of the Breast

1996; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-642-79278-6_24

2197-6767

Michael Baum, John R. Benson,

Angiogenesis and VEGF in Cancer

The world overview of adjuvant trials for early breast cancer published in The Lancet in January 1992 (Early Breast Cancer Trialists' Collaborative Group 1992) provided us with secure data to allow the rational employment of adjuvant systemic chemotherapy and endocrine therapy, but like the process of science in any other walk of life, in answering one set of questions, a new set of questions has emerged. Effectively therefore, the world overview also set the agenda for the next decade of clinical trials in the management of early breast cancer. A whole raft of new questions has been defined concerning the role of endocrine manipulation in both pre- and postmenopausal women.