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The History of the Development and Clinical Use of CB 3717 and ICI D1694

1993; Springer Nature; Linguagem: Inglês

10.1007/978-1-4615-2488-5_27

2214-8019

Stephen Clarke, Ann L. Jackman, Ian Judson,

Folate and B Vitamins Research

In this chapter we would like to review the historical development and use of two anti-folate thymidylate synthase (TS) inhibitors which have so far reached clinical study, CB 3717 and ICI D1694 (Figure 1). Both agents first entered clinical trial at the Royal Marsden Hospital, the clinical centre attached to the Institute of Cancer Research (ICR), CB 3717 in September 1981 and ICI D1694, a decade later in February 1991.