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Bovine Bladder Compliance Increases with Normal Fetal Development

1994; Lippincott Williams & Wilkins; Volume: 152; Issue: 2 Part 2 Linguagem: Inglês

10.1016/s0022-5347(17)32682-4

1527-3792

Laurence S. Baskin, David F. Meaney, Adam Landsman, Steve A. Zderic, Edward J. Macarak,

Urinary Bladder and Prostate Research

No AccessJournal of Urology1 Aug 1994Bovine Bladder Compliance Increases with Normal Fetal Development Laurence Baskin, Dave Meaney, Adam Landsman, Steve A. Zderic, and Edward Macarak Laurence BaskinLaurence Baskin , Dave MeaneyDave Meaney , Adam LandsmanAdam Landsman , Steve A. ZdericSteve A. Zderic , and Edward MacarakEdward Macarak View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)32682-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail In this study we characterized the elastic properties of the normal bovine bladder throughout fetal life, the newborn period and into adulthood. The elasticity of the bladder was measured with a novel circularly clamped bladder testing system. Pressurization of a circularly clamped bladder tissue sample caused the tissue to deflect upward repetitively in the shape of a spherical cap. If the centerline deflection is much larger than the tissue thickness, the elastic modulus, considered the inverse of compliance, can be determined using linear regression techniques. The results of our analyses showed that the elastic modulus decreases in direct proportion with increasing gestational age. These data suggest that during normal development of the bovine fetal bladder there is a progressive change from a rather stiff noncompliant bladder characterized by a high elastic modulus to a compliant bladder with a lower elastic modulus. Moreover, the increase in compliance appears in the developmental period when urine production first occurs. These observations suggest that volume work may be a significant event in the normal development process of the bovine bladder and results in an increase in bladder compliance. Conversely, the poorly compliant fetal bladder may explain some of the transient dilatations of the upper urinary tract which have been documented in utero. Finally, from the newborn period to the mature adult bovine we documented a relatively modest increase in the elastic modulus or decrease in bladder compliance which may reflect the normal aging process. References 1. : Mechanical characterization of membrane like biological tissue. J. Biomech. Eng.1993; 105: 31. Google Scholar 2. : A system to reproduce and quantify the biomechanical environment of the cell. J. Appl. Physiol.1989; 67: 397. Google Scholar 3. : Implantation and development of the conceptus. In: . Edited by . New York: Academic Press1977: 335. Google Scholar 4. : Mechanical properties of urinary bladder. Amer. J. Physiol.1971; 220: 1413. Google Scholar 5. : Urinary bladder wall dynamics. Invest. Urol1972; 9: 520. Google Scholar 6. : Viscoelastic properties of bladder. I. Mechanical model and its mathematical analysis. Invest. Urol.1972; 10: 154. Google Scholar 7. : Physical properties of the urinary detrusor muscle. 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Gynec.1989; 161: 1264. Google Scholar 15. Coplen, D. E., Macarak, E. J. and Levin, R. M.: Developmental changes in normal fetal bovine whole bladder physiology. J. Urol., in press. Google Scholar © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byWei W, Howard P, Kogan B and Macarak E (2018) Urinary Diversion Results in Marked Decreases in Proliferation and Apoptosis in Fetal BladderJournal of Urology, VOL. 188, NO. 4, (1306-1312), Online publication date: 1-Oct-2012.OLSEN L, DALMOSE A, SWINDLE M, DJURHUUS J and JØRGENSEN T (2018) MALE FETAL PIG LOWER URINARY TRACT FUNCTION. PART II: FREE VOIDING PATTERN CLOSE TO TERM AND IN THE NEWBORNJournal of Urology, VOL. 171, NO. 6 Part 2, (2660-2663), Online publication date: 1-Jun-2004.de la rosette J, Smedts F, Schoots C, Hoek H and Laguna P (2018) Changing Patterns of Keratin Expression could be Associated with Functional Maturation of the Developing Human BladderJournal of Urology, VOL. 168, NO. 2, (709-717), Online publication date: 1-Aug-2002.GLASSBERG K (2018) THE VALVE BLADDER SYNDROME: 20 YEARS LATERJournal of Urology, VOL. 166, NO. 4, (1406-1414), Online publication date: 1-Oct-2001.Kaplan E, Richier J, Howard P, Ewalt D and Lin V (2018) Type III Collagen Messenger RNA is Modulated in Non-Compliant Human Bladder TissueJournal of Urology, VOL. 157, NO. 6, (2366-2369), Online publication date: 1-Jun-1997.Baskin L, Hayward S, Young P and Cunha G (2018) Role of Mesenchymal-Epithelial Interactions in Normal Bladder DevelopmentJournal of Urology, VOL. 156, NO. 5, (1820-1827), Online publication date: 1-Nov-1996.Sutherland R, Baskin L, Hayward S and Cunha G (2018) Regeneration of Bladder Urothelium, Smooth Muscle, Blood Vessels and Nerves Into an Acellular Tissue MatrixJournal of Urology, VOL. 156, NO. 2S, (571-577), Online publication date: 1-Aug-1996.Baskin L, Zderic S, Snyder H and Duckett J (2018) Primary Dilated Megaureter: Long-Term FollowupJournal of Urology, VOL. 152, NO. 2 Part 2, (618-621), Online publication date: 1-Aug-1994.Baskin L, Constantinescu S, Duckett J, Snyder H and Macarak E (2018) Type III Collagen Decreases in Normal Fetal Bovine Bladder DevelopmentJournal of Urology, VOL. 152, NO. 2 Part 2, (688-691), Online publication date: 1-Aug-1994. Volume 152Issue 2 Part 2August 1994Page: 692-695 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.Keywordsbladderfetal developmentcomplianceelasticityMetricsAuthor Information Laurence Baskin More articles by this author Dave Meaney More articles by this author Adam Landsman More articles by this author Steve A. Zderic More articles by this author Edward Macarak More articles by this author Expand All Advertisement PDF downloadLoading ...