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Low Dose Intravesical Heparin as Prophylaxis against Recurrent Noninvasive(Stage Ta) Bladder Cancer

1990; Lippincott Williams & Wilkins; Volume: 144; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(17)39542-3

1527-3792

Mikael Bitsch, Gregers G. Hermann, Jens Peter Andersen, Kenneth Steven,

Urinary Bladder and Prostate Research

No AccessJournal of Urology1 Sep 1990Low Dose Intravesical Heparin as Prophylaxis against Recurrent Noninvasive(Stage Ta) Bladder Cancer Mikael Bitsch, Gregers G. Hermann, Jens P. Andersen, and Kenneth Steven Mikael BitschMikael Bitsch , Gregers G. HermannGregers G. Hermann , Jens P. AndersenJens P. Andersen , and Kenneth StevenKenneth Steven View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39542-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A controlled randomized clinical trial was conducted to examine the efficacy of topical low dose heparin (0.125 gm./L, 25,000 units per 1.) as prophylaxis against recurrent noninvasive (stage Ta) transitional cell bladder cancer. Transurethral tumor resection was done with irrigation fluid containing either 1.5% glycine with heparin or glycine solution alone. Tumor recurrence was determined by cystoscopy 4 to 6 months later. There were 70 patients evaluated: 38 in the heparin and 32 in the control group, respectively. The recurrence rate (heparin 74%, control 66%) and the median number of recurrences (heparin 3, range 1 to 15 and control 3, range 1 to 30) were similar (p >0.05) in the 2 groups of patients. These observations show that low dose heparin administered in the irrigation fluid during transurethral resection does not decrease the recurrence rate of noninvasive (stage Ta) bladder cancer. © 1990 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 144Issue 3September 1990Page: 635-636 Advertisement Copyright & Permissions© 1990 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Mikael Bitsch More articles by this author Gregers G. Hermann More articles by this author Jens P. Andersen More articles by this author Kenneth Steven More articles by this author Expand All Advertisement PDF downloadLoading ...