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Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

2015; Massachusetts Medical Society; Volume: 373; Issue: 1 Linguagem: Inglês

10.1056/nejmoa1414799

1533-4406

Tetsuichi Yoshizato, Bogdan Dumitriu, Kohei Hosokawa, Hideki Makishima, Kenichi Yoshida, Danielle Townsley, Aiko Sato‐Otsubo, Yusuke Sato, Delong Liu, Hiromichi Suzuki, Colin O. Wu, Yuichi Shiraishi, Michael J. Clemente, Keisuke Kataoka, Yusuke Shiozawa, Yusuke Okuno, Kenichi Chiba, Hiroko Tanaka, Yasunobu Nagata, Takamasa Katagiri, Ayana Kon, Masashi Sanada, Phillip Scheinberg, Satoru Miyano, Jaroslaw P. Maciejewski, Shinji Nakao, Neal S. Young, Seishi Ogawa,

Cancer Genomics and Diagnostics

In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia. Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many months to years after the diagnosis of aplastic anemia.