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Mouse Models for Tumor Metastasis

2012; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-1-62703-008-3_17

1940-6029

Shengyu Yang, J. Jillian Zhang, Xin-Yun Huang,

Cancer Cells and Metastasis

Tumor metastasis is the main cause of death of cancer patients. Here we describe two mouse models for investigating tumor metastasis. In the first spontaneous metastasis mouse model, 4T1 mouse breast tumor cells are injected into the mammary gland of host mice and the metastasis of 4T1 tumor cells into the lung are examined with a colonogenic assay. In the second experimental metastasis mouse model, luciferase-labeled MDA-MB-231 human breast tumor cells are injected into the tail vein of NOD-SCID immunodeficient mice and the colonization of MDA-MB-231 tumor cells in the lung are monitored using noninvasive bioluminescence imaging.