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The Use of Intravesical Oxybutynin Chloride in Children with Neurogenic Bladder

1991; Lippincott Williams & Wilkins; Volume: 146; Issue: 2 Part 2 Linguagem: Inglês

10.1016/s0022-5347(17)37845-x

1527-3792

Saul P. Greenfield, Margaret Fera,

Pelvic floor disorders treatments

No AccessJournal of Urology1 Aug 1991The Use of Intravesical Oxybutynin Chloride in Children with Neurogenic Bladder Saul P. Greenfield and Margaret Fera Saul P. GreenfieldSaul P. Greenfield More articles by this author and Margaret FeraMargaret Fera More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37845-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Intravesical oxybutynin chloride was administered to 10 children with neurogenic bladder (myelomeningocele in 9 and imperforate anus in 1) and urinary incontinence refractory to regimens of intermittent catheterization and oral anticholinergic medication. Therapy consisted of instillation of 5mg. crushed oxybutynin chloride in 10cc sterile saline twice daily. Of the children 5 (50%) became completely dry day and night, 3 (30%) achieved daytime continence alone, and 2 did not improve clinically and remained in diapers. Urodynamic study revealed increases in bladder capacity up to 335% over baseline and decreases of maximum filling pressures to 63%. No local or systemic side effects were noted. Surgical bladder augmentation was avoided in those who clinically responded to this therapy. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byKrause P, Fuhr U, Schnitker J, Albrecht U, Stein R and Rubenwolf P (2018) Pharmacokinetics of Intravesical Versus Oral Oxybutynin in Healthy Adults: Results of an Open Label, Randomized, Prospective Clinical StudyJournal of Urology, VOL. 190, NO. 5, (1791-1797), Online publication date: 1-Nov-2013.Guerra L, Moher D, Sampson M, Barrowman N, Pike J and Leonard M (2018) Intravesical Oxybutynin for Children With Poorly Compliant Neurogenic Bladder: A Systematic ReviewJournal of Urology, VOL. 180, NO. 3, (1091-1097), Online publication date: 1-Sep-2008.Fader M, Glickman S, Haggar V, Barton R, Brooks R and Malone-Lee J (2018) Intravesical Atropine Compared to Oral Oxybutynin for Neurogenic Detrusor Overactivity: A Double-Blind, Randomized Crossover TrialJournal of Urology, VOL. 177, NO. 1, (208-213), Online publication date: 1-Jan-2007.YOKOYAMA O, YUSUP A, MIWA Y, OYAMA N, AOKI Y and AKINO H (2018) EFFECTS OF TOLTERODINE ON AN OVERACTIVE BLADDER DEPEND ON SUPPRESSION OF C-FIBER BLADDER AFFERENT ACTIVITY IN RATSJournal of Urology, VOL. 174, NO. 5, (2032-2036), Online publication date: 1-Nov-2005.OKI T, KIMURA R, SAITO M, MIYAGAWA I and YAMADA S (2018) DEMONSTRATION OF BLADDER SELECTIVE MUSCARINIC RECEPTOR BINDING BY INTRAVESICAL OXYBUTYNIN TO TREAT OVERACTIVE BLADDERJournal of Urology, VOL. 172, NO. 5, (2059-2064), Online publication date: 1-Nov-2004.YOSHIMURA N and CHANCELLOR M (2018) Current and Future Pharmacological Treatment for Overactive BladderJournal of Urology, VOL. 168, NO. 5, (1897-1913), Online publication date: 1-Nov-2002.Di Stasi S, Giannantoni A, Vespasiani G, Navarra P, Capelli G, Massoud R and Stephen R (2018) INTRAVESICAL ELECTROMOTIVE ADMINISTRATION OF OXYBUTYNIN IN PATIENTS WITH DETRUSOR HYPERREFLEXIA UNRESPONSIVE TO STANDARD ANTICHOLINERGIC 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160, NO. 3 Part 1, (892-896), Online publication date: 1-Sep-1998.Di Stasi S, Giannantoni A, Massoud R, Cortese C, Vespasiani G and Micali F (2018) Electromotive Administration of Oxybutynin into the Human Bladder WallJournal of Urology, VOL. 158, NO. 1, (228-233), Online publication date: 1-Jul-1997.Palmer L, Zebold K, Firlit C and Kaplan W (2018) Complications of Intravesical Oxybutynin Chloride Therapy in the Pediatric Myelomeningocele PopulationJournal of Urology, VOL. 157, NO. 2, (638-640), Online publication date: 1-Feb-1997.Painter K, Vates T, Bukowski T, Fleming P, Freedman A, Smith C, Gonzalez R and Perlmutter A (2018) Long-Term Intravesical Oxybutynin Chloride Therapy in Children with MyelodysplasiaJournal of Urology, VOL. 156, NO. 4, (1459-1462), Online publication date: 1-Oct-1996.Kaplinsky R, Greenfield S, Wan J and Fera M (2018) Expanded Followup of Intravesical Oxybutynin Chloride Use in Children with Neurogenic BladderJournal of Urology, VOL. 156, NO. 2S, (753-756), 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Volume 146Issue 2 Part 2August 1991Page: 532-534 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.Keywordsdrug therapybladder, neurogenicadministration, intravesicalMetricsAuthor Information Saul P. Greenfield More articles by this author Margaret Fera More articles by this author Expand All Advertisement PDF downloadLoading ...