Portal de Periódicos da CAPES

Comparison of Urinary Bladder Function in Sexually Mature and Immature Male and Female Rats

1990; Lippincott Williams & Wilkins; Volume: 143; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(17)40252-7

1527-3792

Alexa L. Chun, Alan J. Wein, Richard C. Harkaway, Robert M. Levin,

Circadian rhythm and melatonin

No AccessJournal of Urology1 Jun 1990Comparison of Urinary Bladder Function in Sexually Mature and Immature Male and Female Rats Alexa L. Chun, Alan J. Wein, Richard Harkaway, and Robert M. Levin Alexa L. ChunAlexa L. Chun , Alan J. WeinAlan J. Wein , Richard HarkawayRichard Harkaway , and Robert M. LevinRobert M. Levin View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)40252-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Although studies exist using both male and female rats, there are virtually no studies that compare male and female bladder function. In this initial study, in-vivo and in-vitro urinary bladder function was investigated in two age groups of male and female rats (sexually immature and sexually mature). These studies compare in-vivo micturition behavior (water intake, urine output, frequency and volume per micturition); and in-vitro whole bladder function (bladder volume/pressure relationships, the ability of the in-vitro bladders to generate pressure and empty in response to bethanechol and field stimulation). The results can be summarized as follows: 1) The 24hour water intake, urine output, and volume per micturition for the mature male rats was significantly greater than that of the mature females with no significant differences among the immature females, mature females, or immature males. 2) There were no significant differences in the frequency of micturition between the 4 groups. 3) Although the average plateau pressures (cystometrograms) of the immature and mature female bladders were greater than that of the immature and mature male bladders, the compliance was similar for all groups. 4) The maximum pressure response of the mature female bladder was significantly greater than pressures generated by bladders in the other three groups; there were no age or sex related differences in the bethanechol log ED50 values. 5) There were no age or sex-related differences in the bethanechol log ED50 values or maximal expulsion responses. 6) Field stimulated bladders from mature animals generated significantly greater intravesical pressures than bladders from immature animals, but, there were no significant differences in maximal pressures attained between mature male and female bladders nor between immature male and female bladders. In conclusion, micturition behavior, and the maximal pressure response to bethanechol changed dramatically with sexual maturity. These results are consistent with the idea that estrogen and other hormones may have a marked influence on bladder function and micturition behavior. (J. Urol, 143: 1267–1271, 1990) © 1990 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byNegoro H, Kanematsu A, Matsuo M, Okamura H, Tabata Y and Ogawa O (2018) Development of Diurnal Micturition Pattern in Mice After WeaningJournal of Urology, VOL. 189, NO. 2, (740-746), Online publication date: 1-Feb-2013.SALMI S, SANTTI R, GUSTAFSSON J and MÁKELÁ S (2018) CO-LOCALIZATION OF ANDROGEN RECEPTOR WITH ESTROGEN RECEPTOR β IN THE LOWER URINARY TRACT OF THE MALE RATJournal of Urology, VOL. 166, NO. 2, (674-677), Online publication date: 1-Aug-2001.RODÓ J, FARRÉ X and MARTÍN E (2018) CYCLOPHOSPHAMIDE-INDUCED HEMORRHAGIC CYSTITIS IN RATS THAT UNDERWENT COLOCYSTOPLASTY:: EXPERIMENTAL STUDYJournal of Urology, VOL. 165, NO. 2, (660-666), Online publication date: 1-Feb-2001.Lehtimaki J, Makela S, Viljamaa J, Yagi A, Paranko J and Santti R (2018) Neonatal Estrogenization of the Male Mouse Results in Urethral DysfunctionJournal of Urology, VOL. 156, NO. 6, (2098-2103), Online publication date: 1-Dec-1996.Eika B, Levin R and Longhurst P (2018) Modulation of Urinary Bladder Function by Sex Hormones in Streptozotocin-Diabetic RatsJournal of Urology, VOL. 152, NO. 2 Part 1, (537-543), Online publication date: 1-Aug-1994. Volume 143Issue 6June 1990Page: 1267-1271 Advertisement Copyright & Permissions© 1990 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Alexa L. Chun More articles by this author Alan J. Wein More articles by this author Richard Harkaway More articles by this author Robert M. Levin More articles by this author Expand All Advertisement PDF downloadLoading ...