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Intake of Passiflora edulis leaf extract improves antioxidant and anti-inflammatory status in rats with 2,4,6-trinitrobenzenesulphonic acid induced colitis

2015; Elsevier BV; Volume: 17; Linguagem: Inglês

10.1016/j.jff.2015.05.034

2214-9414

Cínthia Baú Betim Cazarin, Juliana Kelly da Silva-Maia, Talita Cristina Colomeu, Ângela Giovana Batista, Laura Maria Molina Meletti, Jonas Augusto Rizzato Paschoal, Stanislau Bogusz, Patrícia Aparecida de Campos Braga, Félix Guillermo Reyes Reyes, Fábio Augusto, Luciana Rodrigues de Meirelles, Ricardo de Lima Zollner, Mário Roberto Maróstica,

Animal Nutrition and Physiology

The antioxidant and anti-inflammatory effects of the aqueous extract of Passiflora edulis leaves, which is a source of vitexin, isovitexin and isoorientin, was investigated in a 2,4,6-trinitrobenzenesulphonic acid induced colitis model. The oral intake of P. edulis extract (1100 µg mL−1) improved significantly (P < 0.05) the endogenous antioxidant status and decreased lipid peroxidation in serum, liver, and colon. The consumption of P. edulis extract decreased the level of pro-inflammatory in colon tissue, especially by reducing IL-1β five-fold and TNF-α two-fold compared to the control colitis group. The extract of P. edulis leaves possessed therapeutic activity in healthy rats and in TNBS-induced colitis, especially by controlling the oxidative stress and inflammation observed in this disease.