Portal de Periódicos da CAPES

Assay of aspirin and naproxen analgesia

1976; Wiley; Volume: 19; Issue: 1 Linguagem: Inglês

10.1002/cpt197619118

1532-6535

D. Luke Mahler, William H. Forrest, Colin Brown, Phyllis F. Shroff, H. Earl Gordon, Byron W. Brown, Kenneth E. James,

Analytical Methods in Pharmaceuticals

To establish the relative potency ofnaproxen and aspirinfor oral analgesia, a 4‐point, noncrossover bioassay with placebo control was undertaken with 197 patients. Subjective‐response methods were used to determine two measures of postoperative analgesia over aperiod of 6 hr. With reasonable confidence for an oral analgesic assay, we found 220 mg of naproxen to be equivalent to 600 mg of aspirin for pain relief and 330 mg of naproxen to be equivalent to 600 mg of aspirin for decreased pain intensity.