miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL
2015; Elsevier BV; Volume: 125; Issue: 19 Linguagem: Inglês
10.1182/blood-2014-07-586511
ISSN1528-0020
AutoresValeska Berg, Marion Rusch, Nachiket Vartak, Christian Jüngst, Astrid Schauß, Herbert Waldmann, Christian Hedberg, Christian P. Pallasch, Philippe I. H. Bastiaens, Michael Hallek, Clemens‐Martin Wendtner, Lukas P. Frenzel,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoKey Points APTs as miRNA targets provide a novel molecular mechanism for how primary CLL cells escape from CD95-mediated apoptosis. Palmitoylation as a novel posttranslational modification in CLL might also impact on survival signaling, proliferation, and migration.
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