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BIBTEX RIS

Functional and regenerative effects of local administration of autologous mononuclear bone marrow cells combined with silicone conduit on transected femoral nerve of rabbits

2015; Elsevier BV; Volume: 102; Linguagem: Inglês

10.1016/j.rvsc.2015.07.008

1532-2661

Anelise Bonilla Trindade, Pedro Schestatsky, Vítor Félix Torres, Cristiano Gomes, Giordano Cabral Gianotti, Ana Helena da Rosa Paz, Paula Barros Terraciano, Janete Maria Volpato Marques, Karina Magano Guimarães, Dominguita Lühers Graça, Elizabeth Obino Cirne Lima, Emerson Antônio Contesini,

Mesenchymal stem cell research

The inoculation of cells into injury sites can accelerate and improve the quality of nerve regeneration. This study aimed to evaluate the functional and regenerative effects of mononuclear autologous bone marrow cells (MABMC) combined with silicon conduit grafting in rabbit femoral nerves. Twenty-eight animals were allocated to one of two groups: treatment group (TG) or control group (CG), divided according to the time of evaluation, at either 50 or 75 days. After neurotmesis of the femoral nerve, surgical repair was performed with nerve autografts in silicon conduits, leaving a 5 mm gap in both groups. The TG received MABMC in silicon conduits, and CG received a sham saline inoculum. Histological, clinical and electrophysiological analyses detected no differences between groups, but analysis of leg diameter showed that TG diameters were larger. This cell therapy did not improve regeneration of the femoral nerve, but there was a tendency for better functional recovery.