Impact of Recent Findings on Study Design of Future Autism Clinical Trials
2004; Cambridge University Press; Volume: 9; Issue: 1 Linguagem: Inglês
10.1017/s109285290000835x
ISSN2165-6509
AutoresEric Hollander, Ann Phillips, Bryan H. King, Donald Guthrie, Michael G. Aman, Paul A. Law, Thomas Owley, Ricki Robinson,
Tópico(s)Attention Deficit Hyperactivity Disorder
ResumoABSTRACT There are specific challenges to studying the design of pharmacologic trials in child/adolescent and adult autism, such as subject stratification and parallel versus crossover designs. This article describes how optimal study design is influenced by subject selection and outcome measures chosen. Lessons learned in study design from the Research Units on Pediatric Psychopharmacology Autism Network trial with risperidone, Seaver Center trials with fluoxetine and valproate, Dartmouth trials with amantadine, and National Institutes of Health secretin trials are highlighted. The Internet System for Assessing Autistic Children system for managing multicenter clinical trials in autism and statistical issues in autism research are also described.
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