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the Viral and Cellular Forms of the Abelson (Dbl) Oncogene

1988; Elsevier BV; Linguagem: Inglês

10.1016/s0065-3527(08)60708-3

1557-8399

Naomi Rosenberg, Owen N. Witte,

Eosinophilic Disorders and Syndromes

The Abelson murine leukemia virus (Ab-MLV) has proved to be a useful tool both for virologists interested in the mechanism of transformation and for immunologists interested in lymphocyte differentiation. Although only 17 years have passed since the isolation of Ab-MLV, the advances made during this time tend to obscure much of the early history of Ab-MLV. A review of this information both sets the stage for events that follow and reveals questions about the mechanism of Ab-MLV-cell interaction that remain unanswered today. The roots of the experiment in which Ab-MLV was isolated arise from one of the major areas of RNA tumor virus research in vogue 20-30 years ago. At this time, a number of viruses had been isolated from extracts of spontaneous or radiation-induced murine lymphomas or from tumors that had been maintained by serial transplantation for extended periods of time. Despite the diverse origins of these viruses, most of them induced lymphomas that involved the thymus and some of them could be neutralized by the same lots of antibodies.