STUDIES ON KETOSIS
1935; Elsevier BV; Volume: 108; Issue: 2 Linguagem: Inglês
10.1016/s0021-9258(18)75275-7
ISSN1083-351X
Autores Tópico(s)Diet and metabolism studies
ResumoIn earlier studies from this laboratory it was observed by Deuel, Gulick, and Butts (1) that galactose exerts a superior ketolytic action to glucose in fasting humans and in those receiving ketogenic diets.This finding was confirmed by Butts (2), who showed that fasting rats previously fed on a high galactose diet developed ketosis much more slowly on the administration of diacetic acid than animals which had previously ingested a comparable glucose diet.Apparently this pronounced antiketogenic action of galactose could be accounted for on the basis of a longer retention of liver glycogen and a higher muscle glycogen, in rats fasted as long as 72 hours following diets high in galactose or lactose, than in the corresponding glucose controls (3).Several questions next arose.Do glycogenesis and antiketogenesis go hand in hand?Is it possible that irreversible cleavage products of glycogen or glucose, or compounds not formed in the animal body to any degree, may exert an antiketogenic action without going through the stage of glucose?Finally, do substances other than potential glucose formers exert ketolytic action, or is such an effect confined exclusively to those compounds from which glucose originates in the body?
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