Androgen Binding and Transport in Testis and Epididymis
1976; Elsevier BV; Linguagem: Inglês
10.1016/s0083-6729(08)60961-9
ISSN2162-2620
AutoresE. Martin Ritzén, Lars Hagenäs, V. Hansson, S.C. Weddington, Frank S. French, Shihadeh N. Nayfeh,
Tópico(s)Sexual Differentiation and Disorders
ResumoThis chapter elaborates the different aspects of androgen binding and transport in testin and epididymis. Along with the prostate and the seminal vesicles, the epididymis has long been known to be heavily dependent on androgenic hormones for its normal gross appearance. The testis, however, being the major source of circulating androgenic hormones, escaped detection as a major androgen-responsive tissue. The observations that most androgenic hormones not only stem from the testis, but also exert direct actions on testicular events, were made during studies on the regulation of spermatogenesis. The epididymis is completely dependent on androgenic hormones for its development during fetal life, as well as for its function in the mature male. The nuclear hormone can be extracted as a steroid-protein complex by high ionic strength buffers. The potent antiandrogen cyproterone acetate decreased nuclear uptake of radioactive hormone to the same degree as it inhibited binding to cytoplasmic receptors, also indicating the relationship between cytoplasmic receptors and binding to chromatin.
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