Portal de Periódicos da CAPES

Current Concepts of the Lethal Midline Granuloma Syndrome

1989; Wiley; Volume: 100; Issue: 6 Linguagem: Inglês

10.1177/019459988910000621

1097-6817

John P. Pickens, Louis A. Modica,

Autoimmune and Inflammatory Disorders

"Lethal midline granuloma" is an unusual but devastating spectrum of lymphoproliferative disorders that is now thought to include four entities: idiopathic midline destructive disease, Wegener's granulomatosis, polymorphic reticulosis, and nasal lymphoma. These disorders must be considered in the differential diagnosis of any patient with chronic, nonspecific complaints localized to the upper airway. An aggressive diagnostic and therapeutic approach may significantly decrease morbidity and death resulting from these lesions.