Crystallographic studies on the vitamin B6-assisted enzymic transamination reaction
1994; Linguagem: Inglês
10.1007/978-3-0348-7393-2_5
AutoresJ.N. Jansonius, Jean-Claude Génovésio-Taverne, Michael Hennig, Erhard Hohenester, Margrit Jenny, V.N. Malashkevich, Markus Moser, Rita Müller, Betty Shen, Wilhelm Stark, A. von Stosch, Michael D. Toney,
Tópico(s)Amino Acid Enzymes and Metabolism
ResumoVitamin B6-dependent enzymes involved in amino acid metabolism seem to belong to a small number of independent families. They catalyze a wide variety of reactions on numerous different substrates (Dolphin et al., 1986). The aminotransferases, included in the α-family in the classification of Alexander et al. (1994), have been assigned to one of four subgroups, three of which are evolutionarily related (Mehta et al., 1993). In the following, some aspects of the three-dimensional structures and/or functional properties of aspartate aminotransferase (AspAT; subgroup I), dialkylglycine decarboxylase (DGD; subgroup II), omithine aminotransferase (OAT; subgroup II) and phosphoserine aminotransferase (PSAT; subgroup IV) will be discussed.
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