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C-abl and bcr are rearranged in a Ph1-negative CML patient.

1985; Springer Nature; Volume: 4; Issue: 3 Linguagem: Inglês

10.1002/j.1460-2075.1985.tb03683.x

1460-2075

Claus R. Bartram, E. Kleihauer, Annelies de Klein, Gerard C. Grosveld, J. Teyssier, Nora Heisterkamp, John Groffen,

Eosinophilic Disorders and Syndromes

Chromosomal analysis of a patient with chronic myelocytic leukemia (CML) revealed a translocation (9;12) (q34;q21) without a detectable Philadelphia chromosome (Ph1). Using molecular approaches we demonstrate (i) a rearrangement within the CML breakpoint cluster region (bcr) on chromosome 22, and (ii) a joint translocation of bcr and c-abl oncogene sequences to the derivative chromosome 12. These observations support the view that sequences residing on both chromosome 9 (c-abl) and 22 (bcr) are involved in the generation of CML and suggest that a subset of Ph1-negative patients may in fact belong to the clinical entity of Ph1-positive CML.