The role of autophagy in bacterial infections
2015; Volume: 9; Issue: 3 Linguagem: Inglês
10.5582/bst.2015.01035
ISSN1881-7823
AutoresNayeli Shantal Castrejón-Jiménez, Kahiry Leyva-Paredes, Juan Carlos Hernández-González, Julieta Luna‐Herrera, Blanca Estela García‐Pérez,
Tópico(s)Vibrio bacteria research studies
ResumoAutophagy is a highly conserved catabolic process for the degradation of cytosolic components including damaged organelles, protein aggregates, and intracellular bacteria through a lysosome-dependent pathway. Autophagy can be induced in response to stress conditions. Furthermore, autophagy has been described as involved in both innate and adaptive immune responses, and several studies have shown that certain microorganisms can be eliminated by the autophagic route in a process known as xenophagy. However, several pathogens have developed different strategies to evade or exploit autophagy to ensure their survival. Here, we review the role of autophagy in response to bacterial pathogens.
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